Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging

Abstract : Using a Cramer-Rao analysis, we study the theoretical performances of a time and spatially resolved fDOT imaging system for jointly estimating the position and the concentration of a point-wide fluorescent volume in a diffusive sample. We show that the fluorescence lifetime is a critical parameter for the precision of the technique. A time resolved fDOT system that does not use spatial information is also considered. In certain cases, a simple steady-state configuration may be as efficient as this time resolved fDOT system.
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https://hal.archives-ouvertes.fr/hal-00649575
Contributor : Muriel Roche <>
Submitted on : Thursday, December 8, 2011 - 11:20:39 AM
Last modification on : Wednesday, May 15, 2019 - 3:53:08 AM

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Matthieu Boffety, Marc Allain, Anne Sentenac, M. Massonneau, Rémi Carminati. Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging. Biomedical optics express, Optical Society - SOA Publishing, 2011, pp.1626-36. ⟨10.1364/BOE.2.001626⟩. ⟨hal-00649575⟩

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