Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation.

Linda Cambier (1) , Pascal Pomiès (1)

1 CRBM - Centre de recherche en Biologie Cellulaire

The skALP isoform has been shown to play a critical role in actin organization and anchorage within the Z-discs of skeletal muscles, but no data is available on the function of the smALP isoform in skeletal muscle cells. Here, we show that upon induction of differentiation a nuclear translocation of smALP from the cytoplasm to the nucleus of C2C12 myoblasts, concomitant to an up-regulation of the protein expression, occurs in parallel with the nuclear accumulation of myogenin. Moreover, we demonstrate that the LIM domain of smALP is essential for the nuclear translocation of the protein.

Domaines: Biochimie, Biologie Moléculaire

Linda Cambier, Pascal Pomiès. Nuclear translocation of the cytoskeleton-associated protein, smALP, upon induction of skeletal muscle differentiation.. Biochemical and Biophysical Research Communications, 2011, 409 (4), pp.628-33. ⟨10.1016/j.bbrc.2011.05.054⟩. ⟨hal-00649540⟩