The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH - Towards novel bacterial antiadhesives

M. Durka (1) , K. Buffet (1) , J. Iehl (2) , M. Holler (2) , J.-F. Nierengarten (2) , J. Taganna (3) , J. Bouckaert (3, 4) , Stéphane P. Vincent (1)

1 Laboratoire de Chimie Bio-Organique
2 Laboratoire de Chimie des Matériaux Moléculaires
3 SBB - Structural Biology Brussels
4 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576

Fullerene hexakis-adducts bearing 12 peripheral mannose moieties have been prepared by grafting sugar derivatives onto the fullerene core and assayed as inhibitors of FimH, a bacterial adhesin, using isothermal titration calorimetry, surface plasmon resonance and hemagglutination assays.

Domaines: Biochimie [q-bio.BM]

M. Durka, K. Buffet, J. Iehl, M. Holler, J.-F. Nierengarten, et al.. The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH - Towards novel bacterial antiadhesives. Chemical Communications, 2011, 47 (4), pp.1321-1323. ⟨10.1039/c0cc04468g⟩. ⟨hal-00641736⟩