Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk
Résumé
A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1,428 cases and 1,920 controls. Combined data from these and previously genotyped series (2,503 cases and 5,789 controls) provided evidence for association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined=1.10x10-7 and 1.30x10-5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.
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PEER_stage2_10.1111%2Fj.1365-2141.2011.08706.x.pdf (442.18 Ko)
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