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A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure

Abstract : We propose a model that characterizes and links the complexity and diversity of clinically observed hepatitis C viral kinetics to sustained virologic response (SVR)--the primary clinical end point of hepatitis C treatment, defined as an undetectable viral load at 24 weeks after completion of treatment)--in patients with chronic hepatitis C (CHC) who have received treatment with peginterferon α-2a ± ribavirin. The new attributes of our hepatitis C viral kinetic model are (i) the implementation of a cure/viral eradication boundary, (ii) employment of all hepatitis C virus (HCV) RNA measurements, including those below the lower limit of quantification (LLOQ), and (iii) implementation of a population modeling approach. The model demonstrated excellent positive (99.3%) and negative (97.1%) predictive values for SVR as well as high sensitivity (96.6%) and specificity (99.4%). The proposed viral kinetic model provides a framework for mechanistic exploration of treatment outcome and permits evaluation of alternative CHC treatment options with the ultimate aim of developing and testing hypotheses for personalizing treatments in this disease.
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https://hal.archives-ouvertes.fr/hal-00637434
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Submitted on : Wednesday, November 2, 2011 - 10:18:44 AM
Last modification on : Tuesday, December 17, 2019 - 1:29:58 AM
Long-term archiving on: : Friday, February 3, 2012 - 2:22:08 AM

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Eric Snoeck, Pascal Chanu, Marc Lavielle, Philippe Jacqmin, Niclas Jonsson, et al.. A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure. Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2010, 87 (6), pp.706-713. ⟨hal-00637434⟩

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