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Chapitre D'ouvrage Année : 2011

Near-infrared luminescent labels and probes based on lanthanide ions and their potential for applications in bioanalytical detection and imaging

Résumé

The use of near-infrared (NIR) light in bioanalytical detection and biological imaging presents certain advantages over UV-visible light in terms of penetration depth, reduction of background signals and decreased phototoxicity. Under suitable conditions, complexes of ytterbium(III)-, neodymium(III)- and erbium (III)-containing organic chromophores may display relatively bright NIR luminescence upon excitation with visible light. This contrasts with the more commonly studied visibly luminescent europium(III) and terbium(III) complexes, which generally need UV or blue light for excitation. We discuss the current knowledge on NIR luminescence of lanthanide complexes (including holmium(III), praseodymium(III) and thulium(III)) in solution. It is suggested that among the NIR luminescent lanthanide complexes, ytterbium(III) complexes are likely to be the most promising candidates for biophotonic applications. The study of NIR luminescence and its application in bioanalytical detection are enabled by progress in detector and light source technology, which are also addressed. Recent developments in lanthanide-based NIR luminescent materials, including complexes and doped nanoparticles, are discussed in the light of their potential for bioanalytical application.

Dates et versions

hal-00636864 , version 1 (28-10-2011)

Identifiants

Citer

Martinus H. V. Werts. Near-infrared luminescent labels and probes based on lanthanide ions and their potential for applications in bioanalytical detection and imaging. P. Hänninen and H. Härmä. Lanthanide Luminescence. Photophysical, Analytical and Biological Aspects., Springer, pp.133-159, 2011, Springer Series on Fluorescence, ⟨10.1007/4243_2010_9⟩. ⟨hal-00636864⟩
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