Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Antioxidants and Redox Signaling Année : 2011

Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?

Résumé

Current diagnostic tools to assess neurological injury after aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) have poor discriminatory abilities. Free radicals are associated with the pathophysiology of secondary damage after brain trauma. We examined cerebrospinal fluid (CSF) lipid markers of oxidative stress, isofurans (IsoFs), F4-neuroprostanes (F4-NeuroPs), and F2-isoprostanes (F2-IsoPs), in two casecontrolled studies in patients with aSAH or severe TBI. Patients with aSAH (n = 18) or TBI (n = 18) were age and gender matched with separate control groups. CSF samples were collected from patients within 24 h of the injury. CSF IsoFs and F4-NeuroPs were increased in aSAH patients compared with their controls. In TBI patients, IsoFs and F4-NeuroPs were increased compared with their controls. F2-IsoPs were increased in aSAH patients, but not in TBI patients, compared with their respective controls. CSF IsoFs and F4-NeuroPs are consistently increased after a catastrophic central nervous system injury. These results suggest their measurement may enhance the management of unconscious patients in neurological care.

Domaines

Chimie organique

Dates et versions

hal-00631502 , version 1 (12-10-2011)

Identifiants

Citer

Tomas B. Corcoran, Emilie Mas, Anne E. Barden, Thierry Durand, Jean-Marie Galano, et al.. Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?. Antioxidants and Redox Signaling, 2011, 15 (10), pp.2633-2667. ⟨10.1089/ars.2011.4125⟩. ⟨hal-00631502⟩
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