Non polymeric nanoparticles for photodynamic therapy applications: recent developments

Rima Chouikrat (1, 2) , Aymeric Seve (1, 3) , Régis Vanderesse (3) , Hamanou Benachour (4, 5) , Muriel Barberi-Heyob (4, 5, 6) , Sébastien Richeter (7) , Laurence Raehm (7) , Jean-Olivier Durand (7) , Marc Verelst (2) , Céline Frochot (1, 6)

1 LRGP - Laboratoire Réactions et Génie des Procédés
2 CEMES - Centre d'élaboration de matériaux et d'études structurales
3 LCPM - Laboratoire de Chimie Physique Macromoléculaire
4 CRAN - Centre de Recherche en Automatique de Nancy
5 CAV - Centre Alexis Vautrin
6 PHOTOMED - Médicaments Photoactivables - Photochimiothérapie
7 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

Photodynamic therapy has emerged as an alternative to chemotherapy and radiotherapy for cancer treatment. Nanoparticles have recently been proposed as effective carriers for photosensitizers. Depending on their chemical composition, these can be used for diagnosis and therapy due to the selective accumulation of the photosensitizer in cancer cells in vitro or in tumors in vivo. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools. This review, based on the chemical nature of the nanoparticles will discuss recent advances in the area of non polymeric nanoparticles for photodynamic therapy applications.

Mots clés: Nanoparticle; photosensitizer; photodynamic therapy; reactive oxygen species; nanomedicine; chemotherapy; radiotherapy; cancer; nanoplatforms; polymeric

Domaines: Ingénierie biomédicale

Rima Chouikrat, Aymeric Seve, Régis Vanderesse, Hamanou Benachour, Muriel Barberi-Heyob, et al.. Non polymeric nanoparticles for photodynamic therapy applications: recent developments. Current Medicinal Chemistry, 2012, 19 (6), pp.781-792. ⟨10.2174/092986712799034897⟩. ⟨hal-00631039⟩