Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France.

Abstract : BACKGROUND: Influenza virus is one of the major viral respiratory pathogens infecting human beings. OBJECTIVES: To determine the influenza A virus variants responsible for the 2006-2007 epidemic season in Corsica Island, France. STUDY DESIGN: Of 134 nasal samples of adult patients tested by culture and RT-PCR assays, 85 influenza A strains were identified; 81 (95%) were sub-typed as A/H3N2 and 4 (5%) were sub-typed as A/H1N1. RESULTS: All of the HA sequences of the A/H3N2 viruses circulating in Corsica Island appeared to be closely related to the A/Wisconsin/67/2005 vaccine strain and segregated into two sub-groups that were genetically distinct from other viruses circulating in other countries during 2006/2007. One of these sub-groups was distinguished by the substitution H156Q whereas the second demonstrated at least one of the 3 other additional mutations (R142G, L157S and K173E) common to the HA1 sequence of A/Nepal/921/2006 reference strain. Among the 14 strains of this second sub-group, 10 viral strains had been isolated from vaccinated adult patients. CONCLUSION: These findings suggest that a prospective analysis of the HA sequences of influenza isolates may allow an early detection of newly evolved variants with potential epidemiological inference.
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Article dans une revue
J Clin Virol, 2009, 45 (3), pp.265-8. 〈10.1016/j.jcv.2009.05.004〉
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https://hal.archives-ouvertes.fr/hal-00628455
Contributeur : Laurent Varesi <>
Soumis le : lundi 3 octobre 2011 - 13:36:20
Dernière modification le : jeudi 7 février 2019 - 15:46:34

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Alessandra Falchi, Laurent Varesi, Christophe Arena, Nicolas Leveque, Fanny Renois, et al.. Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France.. J Clin Virol, 2009, 45 (3), pp.265-8. 〈10.1016/j.jcv.2009.05.004〉. 〈hal-00628455〉

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