The mitochondrial citrate carrier: a new player in inflammation

Abstract : The citrate carrier (CIC) catalyzes the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. Herein we show that CIC mRNA and protein markedly increase in LPS-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of nitric oxide, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.
Mots-clés : Life Sciences
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00617325
Contributor : Hal Peer <>
Submitted on : Saturday, August 27, 2011 - 2:51:13 AM
Last modification on : Monday, September 25, 2017 - 1:44:08 PM
Long-term archiving on : Sunday, December 4, 2016 - 1:51:17 PM

File

PEER_stage2_10.1042%2FBJ201112...
Files produced by the author(s)

Identifiers

Collections

Citation

Vittoria Infantino, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, et al.. The mitochondrial citrate carrier: a new player in inflammation. Biochemical Journal, Portland Press, 2011, 438 (3), pp.433-436. ⟨10.1042/BJ20111275⟩. ⟨hal-00617325⟩

Share

Metrics

Record views

126

Files downloads

387