New Lipo-Phosphoramidates for Gene Delivery

Abstract : Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here.
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Submitted on : Wednesday, August 17, 2011 - 3:15:30 PM
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Paul-Alain Jaffres, Aurore Fraix, Christophe Lorilleux, Mathieu Berchel, Hélène Couthon, et al.. New Lipo-Phosphoramidates for Gene Delivery. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2011, 186 (4), pp.918-920. ⟨10.1080/10426507.2010.522639⟩. ⟨hal-00614938⟩



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