New Lipo-Phosphoramidates for Gene Delivery

Paul-Alain Jaffres (1) , Aurore Fraix (1) , Christophe Lorilleux (1) , Mathieu Berchel (1) , Hélène Couthon (1) , Jean-Pierre Haelters (1) , Jean-Jacques Yaouanc (1) , Laure Burel (1) , Philippe Giamarchi (1) , Patrick Midoux (2) , Tristan Montier (3) , Pierre Lehn (3)

1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 CBM - Centre de biophysique moléculaire
3 Génétique moléculaire et génétique épidémiologique

Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here.

Mots clés: transfection; phosphoramides; phospholipids; lipids; gene delivery; Cationic lipids

Domaines: Chimie

Paul-Alain Jaffres, Aurore Fraix, Christophe Lorilleux, Mathieu Berchel, Hélène Couthon, et al.. New Lipo-Phosphoramidates for Gene Delivery. Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (4), pp.918-920. ⟨10.1080/10426507.2010.522639⟩. ⟨hal-00614938⟩