Review article: remission rates achievable by current therapies for inflammatory bowel disease

Laurent Peyrin-Biroulet (1, 2) , Marc Lémann (3)

1 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
2 Service d'Hépato-gastro-entérologie [CHRU Nancy]
3 Service de gastro-entérologie

Background and Aim: To review remission rates with current medical treatments for inflammatory bowel disease (IBD). Methods We searched MEDLINE (source PUBMED, 1966 to January, 2011). Results Induction and maintenance of remission was observed in 20% (range, 9-29.5%) and 53% (range, 36.8-59.6%) of ulcerative colitis (UC) patients treated with oral 5-ASA derivatives. Induction of remission was noted in 52% (range, 48-58%) of Crohn's disease (CD) patients and 54% of UC patients treated with steroids in population-based cohorts. Maintenance of remission was reported in 71% (range, 56-95%) of CD patients on azathioprine over a 6 month to 2 year period and in 60% (range, 41.7-82.4%) in UC at one year or longer. Induction and maintenance of remission was noted in 39% (range, 19.3-66.7%) and 70% (range, 39-90%) of CD patients on methotrexate over a 40 week period. Induction of remission was reported in 32% (range, 25-48%), 26% (range, 18-36%) and 20% (range, 19-23%) of CD patients on infliximab, adalimumab and certolizumab pegol, respectively. The corresponding figures were 45% (range, 39-59%), 43% (range, 40-47%) and 47.9% at weeks 20-30 among initial responders. Induction of remission was observed in 33% (range, 27.5-38.8%) and 18.5% of UC patients on infliximab and adalimumab, respectively. Maintenance of remission was noted in 33% (range, 25.6-36.9%) of UC patients on infliximab at week 30. Approximately one-fifth of CD and UC patients treated with biologicals require intestinal resection after 2-5 years in referral-center studies. Conclusion In the era of biologics, the proportion of patients not entering remission remains high.

Mots clés: Inflammatory bowel disease; Disease-based; Crohn's disease; General practice Topics; Clinical pharmacology Topics

Laurent Peyrin-Biroulet, Marc Lémann. Review article: remission rates achievable by current therapies for inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 2011, 33 (8), pp.870. ⟨10.1111/j.1365-2036.2011.04599.x⟩. ⟨hal-00614698⟩