Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.

Abstract : The supramolecular chiral recognition between rac-2a and several structured RNA leads to a distinct (19)F NMR signal splitting. The (19)F NMR analysis of the diastereomeric pairs formed upon binding of this racemic probe delivers a topological footprint of the RNA. This phenomenon can be exploited to investigate dynamic events involving structural equilibria, as demonstrated in a melting experiment. This work provides a proof of concept that small fluorinated moderate binders can act as external probes of RNA structures.
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Article dans une revue
Journal of the American Chemical Society, American Chemical Society, 2010, 132 (38), pp.13111-3. 〈10.1021/ja1037885〉
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Soumis le : vendredi 12 août 2011 - 15:09:45
Dernière modification le : jeudi 7 février 2019 - 16:32:48

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Roba Moumné, Morgane Pasco, Elise Prost, Thomas Lecourt, Laurent Micouin, et al.. Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.. Journal of the American Chemical Society, American Chemical Society, 2010, 132 (38), pp.13111-3. 〈10.1021/ja1037885〉. 〈hal-00614591〉

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