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Eosinophils are required for the maintenance of plasma cells in the bone marrow

Abstract : Plasma cells are of crucial importance for long-term immune protection. It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils colocalized with plasma cells and were the key providers of plasma cell survival factors. In vitro, eosinophils supported plasma cell survival by secreting APRIL and IL-6. In eosinophil-deficient mice, plasma cell numbers were significantly reduced in the bone marrow both at steady state and after immunization. Reconstitution experiments showed that eosinophils were crucial for bone marrow retention of plasma cells. Moreover, depletion of eosinophils induced apoptosis in long-lived bone marrow plasma cells. These findings demonstrate that the long-term maintenance of plasma cells in the bone marrow requires eosinophils.
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Submitted on : Wednesday, August 3, 2011 - 9:32:44 AM
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Claudia Berek, van Trung Chu, Toralf T.R. Roch, Gudrun Steinhauser, Simon S.F. Fillatreau, et al.. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nature Immunology, Nature Publishing Group, 2011, ⟨10.1038/ni.1981⟩. ⟨hal-00613147⟩

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