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Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow.

Abstract : In the bone marrow (BM), stromal cells constitute a supportive tissue indispensable for the generation of pro-B/pre-BI, pre-BII, and immature B lymphocytes. IL-7-producing stromal cells constitute a cellular niche for pro-B/pre-BI cells, but no specific stromal cell microenvironment was identified for pre-BII cells expressing a functional pre-B cell receptor (pre-BCR). However expression of the pre-BCR represents a crucial checkpoint during B-cell development. We recently demonstrated that the stromal cell derived-galectin1 (GAL1) is a ligand for the pre-BCR, involved in the proliferation and differentiation of normal mouse pre-BII cells. Here we show that nonhematopoietic osteoblasts and reticular cells in the BM express GAL1. We observed that pre-BII cells, unlike the other B-cell subsets, were specifically localized in close contact with GAL1(+) reticular cells. We also determined that IL-7(+) and GAL1(+) cells represent 2 distinct mesenchymal populations with different BM localization. These results demonstrate the existence of a pre-BII specific stromal cell niche and indicate that early B cells move from IL-7(+) to GAL1(+) supportive BM niches during their development.
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https://hal.archives-ouvertes.fr/hal-00611505
Contributor : Marie Laure Haon <>
Submitted on : Tuesday, July 26, 2011 - 2:51:30 PM
Last modification on : Wednesday, January 29, 2020 - 11:10:03 AM

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Frédéric Mourcin, Caroline Breton, Julie Tellier, Priyanka Narang, Lionel Chasson, et al.. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow.. Blood, American Society of Hematology, 2011, 117 (24), pp.6552-61. ⟨10.1182/blood-2010-12-323113⟩. ⟨hal-00611505⟩

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