Nomenclature of monocytes and dendritic cells in blood.

Loems Ziegler-Heitbrock (1, 2) , Petronela Ancuta (3) , Suzanne Crowe (4) , Marc Dalod (5) , Veronika Grau (6) , Derek N Hart (7) , Pieter J M Leenen (8) , Yong-Jun Liu (9) , Gordon Macpherson (10) , Gwendalyn J Randolph (9, 11) , Juergen Scherberich (12) , Juergen Schmitz (13) , Ken Shortman (14) , Silvano Sozzani (15) , Herbert Strobl (16) , Marek Zembala (17) , Jonathan M Austyn (10) , Manfred B Lutz (18, 19)

1 Helmholtz Zentrum München = German Research Center for Environmental Health
2 MRC Toxicology Unit
3 Unite de Recherches en Immunologie Humaine
4 Macfarlane Burnet Institute for Medical Research
5 CIML - Centre d'Immunologie de Marseille - Luminy
6 Department of General and Thoracic Surgery
7 Anzac Research Institute
8 Erasmus MC - Erasmus University Medical Center [Rotterdam]
9 Department of immunology
10 University of Oxford
11 NYU - New York University School of Medicine
12 MVP - Max Von Pettenkofer Institute
13 Miltenyi Biotec
14 WEHI - The Walter and Eliza Hall Institute of Medical Research
15 GPI - General Pathology and Immunology
16 Medizinische Universität Wien = Medical University of Vienna
17 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
18 Lehrstuhl für Regelungstechnik [Erlangen]
19 JMU - Julius-Maximilians-Universität Würzburg

Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense. Over recent years these cells have been characterized in detail with the use of cell surface markers and flow cytometry, and subpopulations have been described. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. This classification has been approved by the Nomenclature Committee of the International Union of Immunological Societies, and we are convinced that it will facilitate communication among experts and in the wider scientific community.

Domaines: Immunologie

Loems Ziegler-Heitbrock, Petronela Ancuta, Suzanne Crowe, Marc Dalod, Veronika Grau, et al.. Nomenclature of monocytes and dendritic cells in blood.. Blood, 2010, 116 (16), pp.e74-80. ⟨10.1182/blood-2010-02-258558⟩. ⟨hal-00611173⟩