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G. At, N=3467) other (m=0, N=727) [0

G. At, N=3563) other (m=0, N=737) [0

G. At, N=3412) other (m=0, N=816) [0

S. Figure, Derived allele frequencies spectra obtained for the HapMap YRI sample, for high recombination regions (as defined by the distance to recombination hotspots) The ancestral and derived alleles were determined using a maximum likelihood method that takes into account CpG hypermutability (Duret and Arndt, 2008). m represents the mean derived allele frequency, and N is the number of SNPs in each category

A. At, N=223) other (m=0

A. Gc, 16, N=118) GC ? AT (m=0.13, N=255) other (m=0.1, N=63)

S. Figure, Derived allele frequencies spectra obtained for the Lohmueller AFR sample, for high recombination regions (as defined by the distance to recombination hotspots), 2008.

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