Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease

Marco Bisaglia (1) , Maria Eugenia Soriano (2) , Irene Arduini (1) , Stefano Mammi (3) , Luigi Bubacco (1)

1 Department of Biology
2 Medical and Surgical Sciences
3 Unipd - Università degli Studi di Padova = University of Padua

Oxidative stress and mitochondrial dysfunction, especially at the level of complex I of the electronic transport chain, have been proposed to be involved in the pathogenesis of Parkinson disease (PD). A plausible source of oxidative stress in nigral dopaminergic neurons is the redox reactions that specifically involve dopamine (DA) and produce various toxic molecules, i.e., free radicals and quinone species (DAQ). It has been shown that DA oxidation products can induce various forms of mitochondrial dysfunction, such as mitochondrial swelling and decreased electron transport chain activity.

Mots clés: Dopamine quinones; glutathione; mitochondria; NADH; NMR

Marco Bisaglia, Maria Eugenia Soriano, Irene Arduini, Stefano Mammi, Luigi Bubacco. Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (9), pp.699. ⟨10.1016/j.bbadis.2010.06.006⟩. ⟨hal-00608985⟩