Cytochrome P450 1A1 expression in cetacean skin biopsies from the Indian Ocean

Abstract : The study describes cytochrome P-450 1A1 (CYPA1) expression in the skin of different cetacean species (Megaptera novaeangliae, n= 15; Stenella attenuata, n=7 and Stenella longirostris, n= 24) from the Mozambique Channel island of Mayotte. Immunohistochemical examination was performed with a monoclonal antibody against scup cytochrome CYPA1. The sex was determined using a molecular approach consisting in the genotyping sex-specific genes. CYPA1 was detected at the junction between epidermis and blubber on dolphins only, mostly in the endothelial cells. Similar observation was obtained in the dermis of one M. novaeangliae. Immunohistochemical slides were scored to evaluate the expression of the CYPA1 and a higher expression was observed in S. longirostris, suggesting a higher exposure to pollutants for this species. The difference of expression between sexes was not significant.
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Marine Pollution Bulletin, Elsevier, 2011, pp.1317-1319
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Thierry Jauniaux, Frédéric Farnir, Michaël Fontaine, Jeremy Kiszka, Michael Sarlet, et al.. Cytochrome P450 1A1 expression in cetacean skin biopsies from the Indian Ocean. Marine Pollution Bulletin, Elsevier, 2011, pp.1317-1319. 〈hal-00608678〉

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