Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation

Stéphane Firmin (1, 2) , Peggy Gandia (3) , Diego Morgavi (2) , Georges Houin (3) , Jp Jouany (2) , Gérard Bertin (1) , Hamid Boudra (2)

1 European Regulatory Department
2 URH - Unité de Recherches sur les Herbivores
3 Service Pharmacologie Clinique [CHU Toulouse]

The cell wall of Saccharomyces cerevisiae can bind mycotoxins in vitro but there is scarce information on whether this property decreases the absorption of mycotoxins in vivo. The effect of a yeast cell wall preparation (YCW) on toxicokinetics and balance excretion (urine and faeces) of aflatoxin B1 (AFB1) and ochratoxin A (OTA) was tested in rats after oral administration of each toxin. The 3H-labelled mycotoxins were used at low doses. Co-administration of YCW with AFB1 decreased the extent but not the rate of absorption. Concurrently, radioactivity excreted in faeces increased by up to 55% when compared to controls, whilst the excretion in urine decreased (p < 0.05). The effect of YCW on OTA was less marked, although it increased radioactivity excretion in faeces (up to 16%; p < 0.05) it did not result in changes in urine and toxicokinetic parameters. The in vivo effect is in agreement with the reported in vitro binding ability for these toxins (AFB1 > OTA). In conclusion, these results indicate that YCW could be used to protect monogastric animals against exposure to low dietary levels of selected mycotoxins.

Mots clés: Life Sciences

Domaines: Sciences du Vivant [q-bio]; Informatique [cs]; Sciences de l'Homme et Société

Stéphane Firmin, Peggy Gandia, Diego Morgavi, Georges Houin, Jp Jouany, et al.. Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation. Food Additives and Contaminants, 2010, 27 (08), pp.1153-1160. ⟨10.1080/19440041003801174⟩. ⟨hal-00604043⟩