Kinetics of yttrium-ligand complexation monitored using hyperpolarized (89)Y as a model for gadolinium in contrast agents.

Pascal Miéville , Sami Jannin (1) , Lothar Helm (2, 3) , Geoffrey Bodenhausen (1, 4)

1 ISIC - Institut des sciences et d'ingénierie chimiques
2 LCIB - Laboratoire de Chimie Inorganique et Bioinorganique
3 Laboratoire de Chimie Inorganique et Bioinorganique
4 UPMC - Université Pierre et Marie Curie - Paris 6

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) enhances (89)Y spin magnetization by 3 to 4 orders of magnitude and provides a way to monitor yttrium-ligand complexation "on the fly" by means of (89)Y NMR. In this communication, we show an example of free yttrium Y(3+) being complexed with 1,4,7,10-tetrakis(acetamido)-1,4,7,10-tetraazacyclododecane (DOTAM) to form [Y(DOTAM)(H(2)O)](3+) as a model for gadolinium in contrast agents.

Domaines: Chimie organique

Pascal Miéville, Sami Jannin, Lothar Helm, Geoffrey Bodenhausen. Kinetics of yttrium-ligand complexation monitored using hyperpolarized (89)Y as a model for gadolinium in contrast agents.. Journal of the American Chemical Society, 2010, 132 (14), pp.5006-7. ⟨10.1021/ja1013954⟩. ⟨hal-00596087⟩