Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs

Dirk Heshe (1) , Stephanie Hoogestraat (1) , Christine Brauckmann (2) , Uwe Karst (2) , Joachim Boos (1) , Claudia Lanvers-Kaminsky (1)

1 Department of Paediatric Haematology and Oncology
2 Institute of Inorganic and Analytical chemistry [University of Freiburg] | Institut für Anorganische und Analytische Chemie [Albert-Ludwigs-Universität Freiburg]

Mots clés: DCA; Warburg effect; Cancer; Cisplatin; Cytotoxicity

Dirk Heshe, Stephanie Hoogestraat, Christine Brauckmann, Uwe Karst, Joachim Boos, et al.. Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs. Cancer Chemotherapy and Pharmacology, 2010, 67 (3), pp.647-655. ⟨10.1007/s00280-010-1361-6⟩. ⟨hal-00595954⟩