Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue General and Comparative Endocrinology Année : 2011

Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes.

Dong-Kyu Kim
  • Fonction : Auteur
Eun Bee Cho
  • Fonction : Auteur
Mi Jin Moon
  • Fonction : Auteur
Sumi Park
  • Fonction : Auteur
Jong-Ik Hwang
  • Fonction : Auteur
Stacia A Sower
  • Fonction : Auteur
Jae Young Seong
  • Fonction : Auteur correspondant
  • PersonId : 947514

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Résumé

Gonadotropin-releasing hormone (GnRH) and its G protein-coupled receptor, GnRHR, play a pivotal role in the control of reproduction in vertebrates. To date, many GnRH and GnRHR genes have been identified in a large variety of vertebrate species using conventional biochemical and molecular biological tools in combination with bioinformatic tools. Phylogenetic approaches, primarily based on amino acid sequence identity, make it possible to classify these multiple GnRHs and GnRHRs into several lineages. Four vertebrate GnRH lineages GnRH1, GnRH2, GnRH3, and GnRH4 (for lamprey) are well established. Four vertebrate GnRHR lineages have also been proposed-three for nonmammalian GnRHRs and mammalian GnRHR2 as well as one for mammalian GnRHR1. However, these phylogenetic analyses cannot fully explain the evolutionary origins of each lineage and the relationships among the lineages. Rapid and vast accumulation of genome sequence information for many vertebrate species, together with advances in bioinformatic tools, has allowed large-scale genome comparison to explore the origin and relationship of gene families of interest. The present review discusses the evolutionary mechanism of vertebrate GnRHs and GnRHRs based on extensive genome comparison. In this article, we focus only on vertebrate genomes because of the difficulty in comparing invertebrate and vertebrate genomes due to their marked divergence.

Dates et versions

hal-00586283 , version 1 (15-04-2011)

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Dong-Kyu Kim, Eun Bee Cho, Mi Jin Moon, Sumi Park, Jong-Ik Hwang, et al.. Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes.. General and Comparative Endocrinology, 2011, 170 (1), pp.68-78. ⟨10.1016/j.ygcen.2010.10.018⟩. ⟨hal-00586283⟩
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