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IFI16 is an innate immune sensor for intracellular DNA

Abstract : The detection of intracellular microbial DNA is critical to an appropriate innate immune response, however current knowledge on how such DNA is sensed is limited. Here we identified IFI16, a PYHIN protein, as an intracellular DNA sensor mediating interferon-β (IFN-β) induction. IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Reduction of expression of IFI16, or its murine ortholog p204, by RNA interference inhibited DNA- and herpes simplex virus (HSV)-1-induced gene induction and IRF3 and NF-κB activation. IFI16 (p204) is the first PYHIN protein shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 (TRUNCATED)
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Submitted on : Sunday, April 3, 2011 - 2:50:44 AM
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Andrew G Bowie, Leonie Unterholzner, Sinead E Keating, Marcin Baran, Kristy Amanda Horan, et al.. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology, Nature Publishing Group, 2010, ⟨10.1038/ni.1932⟩. ⟨hal-00582635⟩



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