Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways, Antioxidants & Redox Signaling, vol.8, issue.9-10, pp.1775-1789, 2006. ,
DOI : 10.1089/ars.2006.8.1775
ERK MAP kinase in G1 cell cycle progression and cancer, Cancer Science, vol.17, issue.8, pp.697-702, 2006. ,
DOI : 10.1093/carcin/bgi066
MAP kinase signalling pathways in cancer, Oncogene, vol.4, issue.22, pp.3279-3290, 2007. ,
DOI : 10.1158/0008-5472.CAN-05-0115
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers, Molecular and Cellular Biology, vol.19, issue.4, pp.2435-2444, 1999. ,
DOI : 10.1128/MCB.19.4.2435
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC84036
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals, Annual Review of Cell and Developmental Biology, vol.19, issue.1, pp.91-118, 2003. ,
DOI : 10.1146/annurev.cellbio.19.111401.091942
The JIP family of MAPK scaffold proteins, Biochemical Society Transactions, vol.34, issue.5, pp.828-832, 2006. ,
DOI : 10.1042/BST0340828
Signal Transduction by the JNK Group of MAP Kinases, Cell, vol.103, issue.2, pp.239-252, 2000. ,
DOI : 10.1016/S0092-8674(00)00116-1
RAS oncogenes: The first 30 years, Nature Reviews Cancer, vol.245, issue.9, pp.459-465, 2003. ,
DOI : 10.1038/nrc1193
Wiring diagrams of MAPK regulation by MEKK1, 2, and 3, Biochemistry and Cell Biology, vol.82, issue.6, pp.658-663, 2004. ,
DOI : 10.1139/o04-114
MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer, Oncogene, vol.97, issue.36, pp.4998-5010, 2006. ,
DOI : 10.1038/sj.onc.1209507
Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways, BMB Reports, vol.40, issue.1, pp.40-41, 2007. ,
DOI : 10.5483/BMBRep.2007.40.1.001
One Hundred Years after the Discovery of Alzheimer's Disease. A Turning Point for Therapy?, Journal of Alzheimer's Disease, vol.12, issue.1, pp.37-52, 2007. ,
DOI : 10.3233/JAD-2007-12105
Alzheimer's Disease: cholesterol, membrane rafts, isoprenoids and statins, Journal of Cellular and Molecular Medicine, vol.3, issue.3, pp.11-383, 2007. ,
DOI : 10.1016/j.neuron.2004.08.043
The molecular link between ??- and ??-secretase activity on the amyloid ?? precursor protein, Cellular and Molecular Life Sciences, vol.64, issue.17, pp.2211-2218, 2007. ,
DOI : 10.1007/s00018-007-7219-3
Microtubule-associated protein tau in development, degeneration and protection of neurons, Progress in Neurobiology, vol.85, issue.2, pp.148-175, 2008. ,
DOI : 10.1016/j.pneurobio.2008.03.002
Phosphorylated tau in neuritic plaques of APPsw/Tauvlw transgenic mice and Alzheimer disease, Acta Neuropathologica, vol.299, issue.Pt 3, pp.409-418, 2008. ,
DOI : 10.1007/s00401-008-0420-0
Amyloid Plaque and Neurofibrillary Tangle Pathology in a Regulatable Mouse Model of Alzheimer's Disease, The American Journal of Pathology, vol.173, issue.3, pp.173-762, 2008. ,
DOI : 10.2353/ajpath.2008.080175
The structure and functions of the presenilins, CMLS Cellular and Molecular Life Sciences, vol.62, issue.10, pp.1109-1119, 2005. ,
DOI : 10.1007/s00018-005-4566-9
Mutant presenilins specifically elevate the levels of the 42 residue ?amyloid peptide in vivo: evidence for augmentation of a 42-specific ? secretase, Hum. Mol. Genet, vol.13, pp.159-170, 2004. ,
Gender- and Age-Dependent ??-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease, PLoS ONE, vol.282, issue.4, p.5088, 2009. ,
DOI : 10.1371/journal.pone.0005088.s001
The Non-Amyloidogenic Pathway: Structure and Function of ??-Secretases, Subcell. Biochem, vol.38, pp.105-127, 2005. ,
DOI : 10.1007/0-387-23226-5_5
Purification and cloning of amyloid precursor protein ?-secretase from human brain, Nature, vol.402, pp.537-540, 1999. ,
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and ?APP processing, Nature, vol.407, pp.48-54, 2000. ,
Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE, Science, vol.286, issue.5440, pp.735-741, 1999. ,
DOI : 10.1126/science.286.5440.735
Intracellular amyloid-?? in Alzheimer's disease, Nature Reviews Neuroscience, vol.66, issue.7, pp.499-509, 2007. ,
DOI : 10.1038/nrn2168
Mitochondrial A?: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease, FASEB J, vol.19, pp.2040-2041, 2005. ,
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases, Nature, vol.175, issue.7113, pp.787-795, 2006. ,
DOI : 10.1038/nature05292
Oxidative stress hypothesis in Alzheimer???s disease: a reappraisal, Trends in Pharmacological Sciences, vol.29, issue.12, pp.609-615, 2008. ,
DOI : 10.1016/j.tips.2008.09.001
The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer???s Disease, Neurosignals, vol.11, issue.5, pp.270-281, 2002. ,
DOI : 10.1159/000067426
Hydrogen Peroxide Is Generated during the Very Early Stages of Aggregation of the Amyloid Peptides Implicated in Alzheimer Disease and Familial British Dementia, Journal of Biological Chemistry, vol.280, issue.43, pp.35789-35792, 2005. ,
DOI : 10.1074/jbc.C500238200
Calcium-Sensing Receptor (CaSR) in Human Brains Pathophysiology: Roles in Late-Onset Alzheimers Disease (LOAD), Current Pharmaceutical Biotechnology, vol.10, issue.3, pp.317-326, 2009. ,
DOI : 10.2174/138920109787847501
Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding ?A plaques in APP Tg2576 mice, Neuropathol. Appl. Neurobiol, pp.30-491, 2004. ,
Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation: OXIDATIVE STRESS, CASPASES, AND THE JNK PATHWAY, Journal of Biological Chemistry, vol.278, issue.30, pp.278-28294, 2003. ,
DOI : 10.1074/jbc.M212265200
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death, J. Neurochem, vol.84, pp.864-877, 2003. ,
Tabaton, ?-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways, J. Neurochem, pp.92-628, 2005. ,
Hydrogen peroxide promotes A? production through JNK-dependent activation of ?secretase, J. Biol. Chem, pp.283-17721, 2008. ,
JNK regulates APP cleavage and degradation in a model of Alzheimer's disease, Neurobiology of Disease, vol.33, issue.3, pp.33-518, 2009. ,
DOI : 10.1016/j.nbd.2008.12.014
The Amyloid-beta Precursor Protein Is Phosphorylated via Distinct Pathways during Differentiation, Mitosis, Stress, and Degeneration, Molecular Biology of the Cell, vol.18, issue.10, pp.3835-3844, 2007. ,
DOI : 10.1091/mbc.E06-07-0625
The ASK1-MAP Kinase Signaling in ER Stress and Neurodegenerative Diseases, Current Molecular Medicine, vol.6, issue.1, pp.87-97, 2006. ,
DOI : 10.2174/156652406775574541
Tau Phosphorylation in Alzheimer's Disease: Potential Involvement of an APP???MAP Kinase Complex, NeuroMolecular Medicine, vol.5, issue.3, pp.205-218, 2004. ,
DOI : 10.1385/NMM:5:3:205
Interaction of ASK1 and the ?amyloid precursor protein in a stress-signaling complex, Neurobiol. Dis, pp.28-65, 2007. ,
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain, The EMBO Journal, vol.276, issue.16, pp.2944-2955, 2005. ,
DOI : 10.1038/sj.emboj.7600757
JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1, Neurobiol. Aging, vol.30, pp.1563-1573, 2009. ,
Tumor necrosis factor? , interleukin-1?, and interferon-? stimulate ?-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway, J. Biol. Chem, pp.279-49523, 2004. ,
Transforming growth factor ?2 is a neuronal death-inducing ligand for amyloid-? precursor protein, Mol. Cell. Biol, pp.25-9304, 2005. ,
Molecular pathogenesis of Parkinson's disease, Human Molecular Genetics, vol.14, issue.18, pp.2749-2755, 2005. ,
DOI : 10.1093/hmg/ddi308
Non-motor symptoms in Parkinson???s disease, European Journal of Neurology, vol.51, issue.s1, pp.14-20, 2008. ,
DOI : 10.1002/mds.10417
Parkinson's disease: from monogenic forms to genetic susceptibility factors, Human Molecular Genetics, vol.18, issue.R1, pp.48-59, 2009. ,
DOI : 10.1093/hmg/ddp012
?-synuclein in Lewy bodies, Nature, vol.388, pp.839-840, 1997. ,
Mice lacking ?-synuclein display functional deficits in the nigrostriatal dopamine system, Neuron, vol.25, pp.239-252, 2000. ,
Mutation in the ?-synuclein gene identified in families with Parkinson's disease, Science, vol.276, pp.2045-2047, 1997. ,
Gwinn-Hardy, ?-Synuclein locus triplication causes Parkinson's disease, Science, vol.302, issue.841, 2003. ,
Destee, ?-synuclein locus duplication as a cause of familial Parkinson's disease, Lancet, vol.364, pp.1167-1169, 2004. ,
??-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease, Nature Neuroscience, vol.165, issue.5, pp.657-663, 2005. ,
DOI : 10.1042/BA20020004
Polo-like kinase 2 (PLK2) phosphorylates ?-synuclein at serine 129 in central nervous system, J. Biol. Chem, vol.284, pp.2598-2602, 2009. ,
Ubiquitination of ??-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function, Journal of Biological Chemistry, vol.278, issue.45, pp.278-44405, 2003. ,
DOI : 10.1074/jbc.M308041200
Oxidative Damage Linked to Neurodegeneration by Selective alpha -Synuclein Nitration in Synucleinopathy Lesions, Science, vol.290, issue.5493, pp.985-989, 2000. ,
DOI : 10.1126/science.290.5493.985
Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human ??-Synuclein(1-120): Implications for Lewy Body Disorders, Journal of Neuroscience, vol.26, issue.15, pp.3942-3950, 2006. ,
DOI : 10.1523/JNEUROSCI.4965-05.2006
Induction of neuronal death by ?-synuclein, Eur. J. Neurosci, vol.12, pp.3073-3077, 2000. ,
Neuroinflammation in Parkinson's disease: a target for neuroprotection?, The Lancet Neurology, vol.8, issue.4, pp.382-397, 2009. ,
DOI : 10.1016/S1474-4422(09)70062-6
Cell death pathways in Parkinson???s disease: proximal triggers, distal effectors, and final steps, Apoptosis, vol.18, issue.1, pp.478-500, 2009. ,
DOI : 10.1007/s10495-008-0309-3
Oxidative and Inflammatory Pathways in Parkinson???s Disease, Neurochemical Research, vol.190, issue.1, pp.55-65, 2009. ,
DOI : 10.1007/s11064-008-9656-2
Animal models of Parkinson???s disease progression, Acta Neuropathologica, vol.26, issue.Suppl 1, pp.385-398, 2008. ,
DOI : 10.1007/s00401-008-0350-x
Aggregated ??-synuclein activates microglia: a process leading to disease progression in Parkinson's disease, The FASEB Journal, vol.19, issue.6, pp.533-542, 2005. ,
DOI : 10.1096/fj.04-2751com
?-synuclein activates stress signaling protein kinases in THP-1 cells and microglia, Neurobiol. Aging, vol.29, pp.739-752, 2008. ,
McGeer, ?synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells, FASEB J, vol.20, 2000. ,
Mitochondrial import and accumulation of ?-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain, J. Biol. Chem, vol.283, pp.9089-9100, 2008. ,
Mitochondrial association of alpha-synuclein causes oxidative stress, Cellular and Molecular Life Sciences, vol.65, issue.7-8, pp.1272-1284, 2008. ,
DOI : 10.1007/s00018-008-7589-1
Classic toxin-induced animal models of Parkinson's disease: 6- OHDA and MPTP, Cell Tissue Res, pp.318-215, 2004. ,
Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?, Trends in Pharmacological Sciences, vol.30, issue.9, pp.30-475, 2009. ,
DOI : 10.1016/j.tips.2009.06.005
Pesticide use linked to Parkinson's disease, Nature, vol.408, issue.125, 2000. ,
Parkinson's disease and pesticides: a toxicological perspective, Trends in Pharmacological Sciences, vol.29, issue.6, pp.322-329, 2008. ,
DOI : 10.1016/j.tips.2008.03.007
Experimental models of Parkinson's disease, Nature Reviews Neuroscience, vol.55, issue.5, pp.325-334, 2001. ,
DOI : 10.1056/NEJM199810153391603
Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by ??-lipoic acid, The FASEB Journal, vol.21, issue.9, pp.2226-2236, 2007. ,
DOI : 10.1096/fj.06-7580com
)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo, J. Neurochem, pp.75-1200, 2000. ,
Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells, Journal of Neurochemistry, vol.274, issue.1, pp.234-244, 2006. ,
DOI : 10.1074/jbc.274.12.8208
Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease, Movement Disorders, vol.277, issue.6, pp.653-664, 2005. ,
DOI : 10.1002/mds.20390
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?, Trends in Cell Biology, vol.18, issue.4, pp.157-164, 2008. ,
DOI : 10.1016/j.tcb.2008.01.007
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242477
Selective Activation of p38 Mitogen-Activated Protein Kinase in Dopaminergic Neurons of Substantia Nigra Leads to Nuclear Translocation of p53 in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice, Journal of Neuroscience, vol.28, issue.47, pp.12500-12509, 2008. ,
DOI : 10.1523/JNEUROSCI.4511-08.2008
Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats, Cell Death and Differentiation, vol.23, issue.2, pp.381-383, 2007. ,
DOI : 10.1038/sj.cdd.4402010
Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease, Neuroscience Letters, vol.428, issue.2-3, pp.428-82, 2007. ,
DOI : 10.1016/j.neulet.2007.09.032
Rotenoneinduced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells, Toxicol. Sci, pp.79-137, 2004. ,
Basic Fibroblast Growth Factor Protects against Rotenone-Induced Dopaminergic Cell Death through Activation of Extracellular Signal-Regulated Kinases 1/2 and Phosphatidylinositol-3 Kinase Pathways, Journal of Neuroscience, vol.26, issue.17, pp.26-4481, 2006. ,
DOI : 10.1523/JNEUROSCI.4922-05.2006
The Herbicide Paraquat Induces Dopaminergic Nigral Apoptosis through Sustained Activation of the JNK Pathway, Journal of Biological Chemistry, vol.279, issue.31, pp.279-32626, 2004. ,
DOI : 10.1074/jbc.M404596200
Activation of c-Jun N-Terminal Protein Kinase Is a Common Mechanism Underlying Paraquat- and Rotenone-Induced Dopaminergic Cell Apoptosis, Toxicological Sciences, vol.97, issue.1, pp.97-149, 2007. ,
DOI : 10.1093/toxsci/kfm029
Divergent Mechanisms of Paraquat, MPP+, and Rotenone Toxicity: Oxidation of Thioredoxin and Caspase-3 Activation, Toxicological Sciences, vol.95, issue.1, pp.95-163, 2007. ,
DOI : 10.1093/toxsci/kfl125
Targeting JNK3 for the treatment of neurodegenerative disorders, Drug Discovery Today, vol.9, issue.21, pp.932-939, 2004. ,
DOI : 10.1016/S1359-6446(04)03251-9
2 Discovery of Cep-1347/Kt-7515, an Inhibitor of the Jnk/Sapk Pathway for the Treatment of Neurodegenerative Diseases, Prog. Med. Chem, pp.40-63, 2002. ,
DOI : 10.1016/S0079-6468(08)70081-X
Targeting the JNK Signaling Pathway for Stroke and Parkinsons Diseases Therapy, Current Drug Target -CNS & Neurological Disorders, vol.4, issue.1, pp.63-67, 2005. ,
DOI : 10.2174/1568007053005145
Leucine-rich repeat kinase 2: Relevance to Parkinson's disease, The International Journal of Biochemistry & Cell Biology, vol.38, issue.9, pp.1469-1475, 2006. ,
DOI : 10.1016/j.biocel.2006.02.009
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, vol.44, issue.4, pp.601-607, 2004. ,
DOI : 10.1016/j.neuron.2004.11.005
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.16842-16847, 2005. ,
The Parkinson diseaseassociated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4, J. Neurochem, vol.7, issue.109, pp.959-968, 2009. ,
Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity, Neuron, vol.37, issue.5, pp.735-749, 2003. ,
DOI : 10.1016/S0896-6273(03)00084-9
Parkin ubiquitinates the ?-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease, Nat. Med, vol.7, pp.1144-1150, 2001. ,
Parkin interacts with LIM Kinase 1 and reduces its cofilinphosphorylation activity via ubiquitination, Exp. Cell Res, pp.313-2858, 2007. ,
DOI : 10.1016/j.yexcr.2007.04.016
Parkin Protects against the Toxicity Associated with Mutant ??-Synuclein, Neuron, vol.36, issue.6, pp.1007-1019, 2002. ,
DOI : 10.1016/S0896-6273(02)01125-X
Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis, Human Molecular Genetics, vol.13, issue.16, pp.1745-1754, 2004. ,
DOI : 10.1093/hmg/ddh180
URL : http://hmg.oxfordjournals.org/cgi/content/short/13/16/1745
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila, Proceedings of the National Academy of Sciences, vol.102, issue.29, pp.10345-10350, 2005. ,
DOI : 10.1073/pnas.0500346102
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, The Journal of Cell Biology, vol.84, issue.5, pp.795-803, 2008. ,
DOI : 10.1073/pnas.0711845105
Parkin mitochondria in the autophagosome: Figure 1., The Journal of Cell Biology, vol.579, issue.5, pp.757-759, 2008. ,
DOI : 10.1073/pnas.0802814105
Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.5956-5961, 2003. ,
Tumorigenesis and neurodegeneration: two sides of the same coin?, BioEssays, vol.102, issue.8, pp.719-727, 2008. ,
DOI : 10.1002/bies.20784
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation, J. Clin. Invest, vol.119, pp.650-660, 2009. ,
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1), Journal of Neurochemistry, vol.3, issue.1, pp.18-33, 2008. ,
DOI : 10.1038/35037739
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, vol.25, issue.7097, pp.1157-1161, 2006. ,
DOI : 10.1038/nature04788
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase, Proceedings of the National Academy of Sciences, vol.104, issue.37, pp.14807-14812, 2007. ,
DOI : 10.1073/pnas.0703219104
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976193
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis, Human Molecular Genetics, vol.14, issue.9, pp.1231-1241, 2005. ,
DOI : 10.1093/hmg/ddi134
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection, Journal of Neuroscience Research, vol.356, issue.1, pp.123-129, 2009. ,
DOI : 10.1002/jnr.21831
DJ-1 modulates ?-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70, PLoS One, vol.3, p.1884, 2008. ,
Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1, The FASEB Journal, vol.23, issue.8, pp.2478-2489, 2009. ,
DOI : 10.1096/fj.08-125153
DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death, Cell Death and Differentiation, vol.87, issue.6, pp.1030-1041, 2008. ,
DOI : 10.1073/pnas.97.26.14382
Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations, Cell Death and Differentiation, vol.27, issue.3, pp.428-438, 2009. ,
DOI : 10.1038/sj.onc.1203378
The mitochondrial serine protease HtrA2/Omi: an overview, Cell Death and Differentiation, vol.19, issue.3, pp.453-460, 2008. ,
DOI : 10.1038/sj.onc.1208681
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice, Molecular and Cellular Biology, vol.24, issue.22, pp.24-9848, 2004. ,
DOI : 10.1128/MCB.24.22.9848-9862.2004
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease, Human Molecular Genetics, vol.14, issue.15, pp.2099-2111, 2005. ,
DOI : 10.1093/hmg/ddi215
Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not an Essential Component of the pink1/parkin Pathway In Vivo, Journal of Neuroscience, vol.28, issue.53, pp.28-14500, 2008. ,
DOI : 10.1523/JNEUROSCI.5141-08.2008
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1, Nature Cell Biology, vol.22, issue.11, pp.1243-1252, 2007. ,
DOI : 10.1038/ncb1644
Molecular biology of amyotrophic lateral sclerosis: insights from genetics, Nature Reviews Neuroscience, vol.6, issue.2, pp.710-723, 2006. ,
DOI : 10.1038/nrn1971
Pathophysiology of Neurodegeneration in Familial Amyotrophic Lateral Sclerosis, Current Molecular Medicine, vol.9, issue.3, pp.255-272, 2009. ,
DOI : 10.2174/156652409787847173
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations, Ann. Neurol, pp.61-427, 2007. ,
Rethinking ALS: The FUS about TDP-43, Cell, vol.136, issue.6, pp.1001-1004, 2009. ,
DOI : 10.1016/j.cell.2009.03.006
Molecular and cellular pathways of neurodegeneration in motor neurone disease, Journal of Neurology, Neurosurgery & Psychiatry, vol.76, issue.8, pp.1046-1057, 2005. ,
DOI : 10.1136/jnnp.2004.048652
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation, Motor neuron degeneration in mice that express a human Cu, pp.1772-1775, 1994. ,
DOI : 10.1126/science.8209258
Inter- and Intracellular Signaling in Amyotrophic Lateral Sclerosis: Role of p38 Mitogen-Activated Protein Kinase, Neurodegenerative Diseases, vol.2, issue.3-4, pp.128-134, 2005. ,
DOI : 10.1159/000089617
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression, Molecular and Cellular Neuroscience, vol.23, issue.2, pp.180-192, 2003. ,
DOI : 10.1016/S1044-7431(03)00022-8
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice, Brain Research, vol.1045, issue.1-2, pp.1045-185, 2005. ,
DOI : 10.1016/j.brainres.2005.03.037
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death, Neurobiol. Dis, pp.26-332, 2007. ,
Activated p38MAPK Is a Novel Component of the Intracellular Inclusions Found in Human Amyotrophic Lateral Sclerosis and Mutant SOD1 Transgenic Mice, Journal of Neuropathology & Experimental Neurology, vol.63, issue.2, pp.63-113, 2004. ,
DOI : 10.1093/jnen/63.2.113
Miller, p38? stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis, Mol. Cell. Neurosci, pp.26-354, 2004. ,
Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b, J. Cell Sci, vol.113, pp.401-407, 2000. ,
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas, Neuron, vol.35, issue.6, pp.1067-1083, 2002. ,
DOI : 10.1016/S0896-6273(02)00905-4
Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL, Proceedings of the National Academy of Sciences, vol.103, issue.15, pp.6007-6012, 2006. ,
DOI : 10.1073/pnas.0508774103
URL : https://hal.archives-ouvertes.fr/hal-00088942
ERAD: the long road to destruction, Nature Cell Biology, vol.67, issue.8, pp.766-772, 2005. ,
DOI : 10.1016/S1097-2765(04)00212-6
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1, Genes & Development, vol.22, issue.11, pp.1451-1464, 2008. ,
DOI : 10.1101/gad.1640108
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418582
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats, Genes & Development, vol.16, issue.11, pp.1345-1355, 2002. ,
DOI : 10.1101/gad.992302
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186318
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer, Pharmacological Reviews, vol.60, issue.3, pp.60-261, 2008. ,
DOI : 10.1124/pr.107.00106
Hyperactive Ras in developmental disorders and cancer, Nature Reviews Cancer, vol.91, issue.4, pp.295-308, 2007. ,
DOI : 10.1038/nrc2109
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon, Nat. Genet, pp.40-600, 2008. ,
OncogenicK-ras promotes early carcinogenesis in the mouse proximal colon, International Journal of Cancer, vol.32, issue.11, pp.2462-2470, 2008. ,
DOI : 10.1002/ijc.23383
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors, BMC Cancer, vol.113, issue.1, 2008. ,
DOI : 10.1053/gast.1997.v113.pm9352861
Therapeutic strategies for inhibiting oncogenic BRAF signaling, Current Opinion in Pharmacology, vol.8, issue.4, pp.419-426, 2008. ,
DOI : 10.1016/j.coph.2008.06.014
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF, Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF, pp.855-867, 2004. ,
DOI : 10.1016/S0092-8674(04)00215-6
Regulation and Role of Raf-1/B-Raf Heterodimerization, Molecular and Cellular Biology, vol.26, issue.6, pp.26-2262, 2006. ,
DOI : 10.1128/MCB.26.6.2262-2272.2006
Two Transforming C-RAF Germ-Line Mutations Identified in Patients with Therapy-Related Acute Myeloid Leukemia, Cancer Research, vol.66, issue.7, pp.3401-3408, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-0115
MAP kinases and cell migration, Journal of Cell Science, vol.117, issue.20, pp.4619-4628, 2004. ,
DOI : 10.1242/jcs.01481
Regulation of matrix metalloproteinases: an overview, Molecular and Cellular Biochemistry, vol.253, issue.1/2, pp.269-285, 2003. ,
DOI : 10.1023/A:1026028303196
Tumour cell survival signalling by the ERK1/2 pathway, Cell Death and Differentiation, vol.96, issue.3, pp.368-377, 2009. ,
DOI : 10.1074/jbc.M010384200
Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim, Journal of Biological Chemistry, vol.278, issue.21, pp.278-18811, 2003. ,
DOI : 10.1074/jbc.M301010200
FOXOs, cancer and regulation of apoptosis, Oncogene, vol.1, issue.16, pp.2312-2319, 2008. ,
DOI : 10.1074/jbc.M205424200
Unique biology of Mcl-1: therapeutic opportunities in cancer, Curr. Mol. Med, vol.8, pp.138-147, 2008. ,
Review article: pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents, Alimentary Pharmacology & Therapeutics, vol.359, issue.6 Suppl. 11, pp.28-1269, 2008. ,
DOI : 10.1111/j.1365-2036.2008.03857.x
ErbB receptors and signaling pathways in cancer, Current Opinion in Cell Biology, vol.21, issue.2, pp.177-184, 2009. ,
DOI : 10.1016/j.ceb.2008.12.010
Somatic mutations of epidermal growth factor receptor in colorectal carcinoma, Clin. Cancer Res, vol.11, pp.1368-1371, 2005. ,
Emerging Therapeutic Targets in Non-Small Cell Lung Cancer, Proceedings of the American Thoracic Society, vol.6, issue.2, pp.218-223, 2009. ,
DOI : 10.1513/pats.200808-099LC
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy, Science, vol.304, issue.5676, pp.1497-1500, 2004. ,
DOI : 10.1126/science.1099314
Better survival with EGFR exon 19 than exon 21 mutations in gefitinib-treated non-small cell lung cancer patients is due to differential inhibition of downstream signals, Cancer Letters, vol.265, issue.2, pp.307-317, 2008. ,
DOI : 10.1016/j.canlet.2008.02.064
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers, Nat. Med, pp.14-1351, 2008. ,
Targeting RAS and PI3K in lung cancer, Nature Medicine, vol.4, issue.12, pp.1315-1316, 2008. ,
DOI : 10.1038/nm1208-1315
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.89-101, 2004. ,
DOI : 10.1016/j.bbapap.2003.11.016
Tau Therapeutic Strategies for the Treatment of Alzheimers Disease, Current Topics in Medicinal Chemistry, vol.6, issue.6, pp.579-595, 2006. ,
DOI : 10.2174/156802606776743057
A novel p38? MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model, J. Neuroinflammation, vol.4, issue.21, 2007. ,
The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability, Cell Death and Differentiation, vol.171, issue.10, pp.1845-1848, 2007. ,
DOI : 10.1046/j.1471-4159.2001.00046.x
Why have we failed to achieve neuroprotection in Parkinson's disease?, Annals of Neurology, vol.56, issue.suppl 5, pp.101-110, 2008. ,
DOI : 10.1002/ana.21461
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5- ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models, J. Med. Chem, pp.51-5680, 2008. ,
Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition, Cancer Res, pp.65-3356, 2005. ,
From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease, Ann. N. Y. Acad. Sci, pp.973-349, 2002. ,
Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases, Nature Clinical Practice Nephrology, vol.68, issue.1, pp.40-55, 2006. ,
DOI : 10.1038/ncpneph0070
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders, Human Mutation, vol.268, issue.8, pp.29-992, 2008. ,
DOI : 10.1002/humu.20748