Abnormal Mitochondrial Dynamics and Neurodegenerative Diseases

Bo Su (1) , Xinglong Wang (1) , Ling Zheng (2) , George Perry (1, 3) , Mark A. Smith (1) , Xiongwei Zhu (1)

1 Department of Pathology
2 Wuhan University [China]
3 UTSA - The University of Texas at San Antonio

Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration.

Mots clés: Mitochondrial Dynamics; Mitochondrial Dysfunction; Mitochondrial Distribution; Synaptic Dysfunction; DLP1; Alzheimer Disease; Parkinson's disease

Bo Su, Xinglong Wang, Ling Zheng, George Perry, Mark A. Smith, et al.. Abnormal Mitochondrial Dynamics and Neurodegenerative Diseases. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1802 (1), pp.135. ⟨10.1016/j.bbadis.2009.09.013⟩. ⟨hal-00562939⟩