Exploring input-output characteristics of the cerebellar granule neuron: role of synaptic inhibition

Priyanka James (1) , Nimshitha Abdulmanaph (1) , Bipin Nair (1) , Shyam Diwakar (1)

1 School of Biotechnology

Understanding functional role of bursts firing is vital in understanding coding of sensory information [1]. Regulating the burst is related to stimulus properties and neural heterogeneities [2].The granule cells form the largest neuronal population in the mammalian brain and regulate information transfer along the major afferent systems to the cerebellum. Understanding how the granule cell processes information appears critical to understand the cerebellar function. We used a mathematical model of cerebellar granule cell to explore information transmission in mossy fibre - granule cell synapse of the cerebellum. The impact of plasticity changes in excitatory synaptic release probability and variation in intrinsic excitability of granule cell was studied combining the modulatory effects of inhibition. We explored the changes in pre and post synaptic factors to study spiking properties and report their influence on first spike latency and spike amplitude, revealing the indicators of information encoding in individual neurons [3].

Mots clés: Information coding; Plasticity and functional specialization; Biophysical models; Others

Domaines: Neurosciences [q-bio.NC]; Neurosciences

Priyanka James, Nimshitha Abdulmanaph, Bipin Nair, Shyam Diwakar. Exploring input-output characteristics of the cerebellar granule neuron: role of synaptic inhibition. Cinquième conférence plénière française de Neurosciences Computationnelles, "Neurocomp'10", Aug 2010, Lyon, France. ⟨hal-00553409⟩