Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts

Massimo Zucchetti (1) , Daniela Meco (2) , Angela Maria Francesco (2) , Tiziana Servidei (2) , Valentina Patriarca (2) , Gabriella Cusano (2) , Maurizio d'Incalci (1) , Daniele Forestieri (1) , Claudio Pisano (3) , Riccardo Riccardi (2)

1 Department of Oncology
2 Division of Pediatric Oncology
3 Research & Development, Sigma-Tau

Mots clés: Gimatecan; Topoisomerase I; Camptothecin; Pediatric tumor xenografts; Pharmacokinetics

Massimo Zucchetti, Daniela Meco, Angela Maria Francesco, Tiziana Servidei, Valentina Patriarca, et al.. Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts. Cancer Chemotherapy and Pharmacology, 2009, 66 (4), pp.635-641. ⟨10.1007/s00280-009-1201-8⟩. ⟨hal-00552485⟩