THE EXPANDING UNIVERSE OF COHESIN FUNCTIONS: A NEW GENOME STABILITY CARETAKER INVOLVED IN HUMAN DISEASE AND CANCER.

Linda Mannini (1) , Stefania Menga (1) , Antonio Musio (2)

1 Istituto di Tecnologie Biomediche C.N.R., Unita' di Pisa
2 ITB - Istituto di Tecnologie Biomediche [Pisa]

Cohesin is responsible for sister chromatid cohesion, ensuring the correct chromosome segregation. Beyond this role, cohesin and regulatory cohesin genes seem to play a role in preserving genome stability and gene transcription regulation. DNA damage is thought to be a major culprit for many human diseases, including cancer. Our present knowledge of the molecular basis underlying genome instability is extremely limited. Mutations in cohesin genes cause human diseases such as the Cornelia de Lange syndrome and the Roberts syndrome/SC phocomelia, and all the cell lines derived from affected patients show genome instability. Cohesin mutations have also been identified in colorectal cancer. Here, we will discuss the human disorders caused by the alterations of cohesin function, with emphasis on the emerging role of cohesin as a genome stability caretaker.

Mots clés: Life Sciences

Linda Mannini, Stefania Menga, Antonio Musio. THE EXPANDING UNIVERSE OF COHESIN FUNCTIONS: A NEW GENOME STABILITY CARETAKER INVOLVED IN HUMAN DISEASE AND CANCER.. Human Mutation, 2010, 31 (6), pp.623. ⟨10.1002/humu.21252⟩. ⟨hal-00552379⟩