The T-ALL paradox in cancer.

Trang Hoang (1) , Thu Hoang (2)

1 IRIC - Institut de Recherche en Immunologie et en Cancérologie [UdeM-Montréal]
2 MAP5 - UMR 8145 - Mathématiques Appliquées Paris 5

Overexpression of T cell leukemia homeobox 1 (TLX1) occurs in some leukemias. New findings in mice and humans show how TLX1 drives chromosomal aberrations and deletions of tumor suppressor genes during T-cell transformation (pages 13211327). Surprisingly, its expression does not correlate with bad prognosis.

Domaines: Cancer

Trang Hoang, Thu Hoang. The T-ALL paradox in cancer.. Nature Medicine, 2010, 16 (11), pp.1185-6. ⟨10.1038/nm1110-1185⟩. ⟨hal-00545400⟩