Detection of small variations in shape between two chromatographic peaks

Hervé Rix 1, *
* Corresponding author
Abstract : The detection of an impurity in a visually single peak by means of the “Distribution Function Method” necessitates a thorough control of every parameter which influences the shape of a peak. In particular, the heights of the peaks compared must be as equal as possible when the chromatographic response is not a linear function of the injected concentration. The Distribution Function Method can also be used for the determination of the region in which the chromatographic response is linear.
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Submitted on : Tuesday, December 7, 2010 - 12:21:51 PM
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Hervé Rix. Detection of small variations in shape between two chromatographic peaks. Journal of Chromatography A, Elsevier, 1981, Journal of Chromatography A Volume 204, 16 January 1981, Pages 163-165. 〈hal-00544127〉

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