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A hierarchical classification of polysaccharide lyases for glycogenomics

Abstract : Carbohydrate-active enzymes face large substrate diversity in a highly selective manner with only a limited number of available folds. They are therefore subjected to multiple divergent and convergent evolutionary events. This and their frequent modularity render their functional annotation in genomes difficult in a number of cases. A classification of polysaccharide lyases (the enzymes that cleave polysaccharides using an elimination instead of a hydrolytic mechanism) is presented thoroughly for the first time. Based on the analysis of a large panel of experimentally characterized polysaccharide lyases, we examined the correlation of various enzyme properties with the three levels of the classification: fold, families and subfamilies. The resulting hierarchical classification, which should help annotate relevant genes in genomic efforts, is available and constantly updated at the Carbohydrate-Active Enzymes Database (www.cazy.org).
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Submitted on : Thursday, November 25, 2010 - 2:51:36 AM
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Vincent Lombard, Thomas Bernard, Corinne Rancurel, Harry Brumer, Pedro M. Coutinho, et al.. A hierarchical classification of polysaccharide lyases for glycogenomics. Biochemical Journal, Portland Press, 2010, 432 (3), pp.437-444. ⟨10.1042/BJ20101185⟩. ⟨hal-00539724⟩

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