Meiosis: A PRDM9 Guide to the Hotspots of Recombination

A. Hochwagen , Gabriel Marais (1)

1 Sexe et évolution

During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

Domaines: Autre [q-bio.OT]

A. Hochwagen, Gabriel Marais. Meiosis: A PRDM9 Guide to the Hotspots of Recombination. Current Biology - CB, 2010, 20 (6), pp.R271-R274. ⟨10.1016/j.cub.2010.01.048⟩. ⟨hal-00539455⟩