Mitochondrial diseases and the role of the yeast models.

Abstract : Nowadays, mitochondrial diseases are recognized and studied with much attention and they cannot be considered anymore as 'rare diseases'. Yeast has been an instrumental organism to understand the genetic and molecular aspects of the many roles of mitochondria within the cells. Thanks to the general conservation of mitochondrial genes and pathways between human and yeast, it can also be used to model some diseases. In this review, we focus on the most recent topics, exemplifying those for which yeast models have been especially valuable.
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Contributor : Marie-Claude Denner <>
Submitted on : Monday, November 22, 2010 - 10:51:06 AM
Last modification on : Thursday, January 11, 2018 - 6:19:24 AM

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Teresa Rinaldi, Cristina Dallabona, Ileana Ferrero, Laura Frontali, Monique Bolotin-Fukuhara. Mitochondrial diseases and the role of the yeast models.. FEMS Yeast Research, Oxford University Press (OUP), 2010, 10 (8), pp.1006-22. ⟨10.1111/j.1567-1364.2010.00685.x⟩. ⟨hal-00538244⟩

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