H. Abe, Y. Yanagawa, K. Kanbara, K. Maemura, H. Hayasaki et al., Epithelial Localization of Green Fluorescent Protein-Positive Cells in Epididymis of the GAD67-GFP Knock-in Mouse, Journal of Andrology, vol.26, issue.5, pp.568-577, 2005.
DOI : 10.2164/jandrol.04157

T. Aguado, K. Monory, J. Palazuelos, N. Stella, B. Cravatt et al., The endocannabinoid system drives neural progenitor proliferation, The FASEB Journal, vol.19, pp.1704-1706, 2005.
DOI : 10.1096/fj.05-3995fje

T. Aguado, J. Palazuelos, K. Monory, N. Stella, B. Cravatt et al., The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells, Journal of Neuroscience, vol.26, issue.5, pp.1551-1561, 2006.
DOI : 10.1523/JNEUROSCI.3101-05.2006

A. Arevalo-martin, D. Garcia-ovejero, A. Rubio-araiz, O. Gomez, F. Molina-holgado et al., Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor???1 and cannabinoid receptor???2, European Journal of Neuroscience, vol.117, issue.6, pp.1548-1559, 2007.
DOI : 10.1111/j.1460-9568.2007.05782.x

D. Baker, G. Pryce, W. L. Davies, and C. R. Hiley, In silico patent searching reveals a new cannabinoid receptor, Trends in Pharmacological Sciences, vol.27, issue.1, pp.1-4, 2006.
DOI : 10.1016/j.tips.2005.11.003

P. Berghuis, M. B. Dobszay, R. M. Ibanez, P. Ernfors, and T. Harkany, Turning the heterogeneous into homogeneous: studies on selectively isolated GABAergic interneuron subsets, International Journal of Developmental Neuroscience, vol.22, issue.7, pp.533-543, 2004.
DOI : 10.1016/j.ijdevneu.2004.07.012

P. Berghuis, M. B. Dobszay, X. Wang, S. Spano, F. Ledda et al., Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor, Proc. Natl. Acad. Sci. U. S. A, 2005.
DOI : 10.1073/pnas.0509494102

P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder et al., Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity, Science, vol.316, issue.5828, pp.1212-1216, 2007.
DOI : 10.1126/science.1137406

C. Bernard, M. Milh, Y. M. Morozov, B. Ari, Y. Freund et al., Altering cannabinoid signaling during development disrupts neuronal activity, Proceedings of the National Academy of Sciences, vol.102, issue.26, pp.9388-9393, 2005.
DOI : 10.1073/pnas.0409641102

URL : https://hal.archives-ouvertes.fr/inserm-00484366

F. Berrendero, N. Sepe, J. A. Ramos, M. Di, V. Fernandez-ruiz et al., Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period, Synapse, vol.218, issue.3, pp.181-191, 1999.
DOI : 10.1002/(SICI)1098-2396(19990901)33:3<181::AID-SYN3>3.0.CO;2-R

T. Bisogno, F. Howell, G. Williams, A. Minassi, M. G. Cascio et al., Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain, The Journal of Cell Biology, vol.1254, issue.3, pp.463-468, 2003.
DOI : 10.1016/0378-1119(91)90391-N

A. J. Brown, Novel cannabinoid receptors, British Journal of Pharmacology, vol.58, issue.Suppl A, pp.567-575, 2007.
DOI : 10.1038/sj.bjp.0707481

A. A. Coutts, S. Anavi-goffer, R. A. Ross, D. J. Macewan, K. Mackie et al., Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons, J. Neurosci, vol.21, pp.2425-2433, 2001.

B. F. Cravatt, D. K. Giang, S. P. Mayfield, D. L. Boger, R. A. Lerner et al., Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides, Nature, vol.384, issue.6604, pp.83-87, 1996.
DOI : 10.1038/384083a0

T. L. Daigle, C. S. Kearn, and K. Mackie, Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling, Neuropharmacology, vol.54, issue.1, pp.36-44, 2008.
DOI : 10.1016/j.neuropharm.2007.06.005

P. Derkinderen, M. Toutant, F. Burgaya, L. Bert, M. Siciliano et al., Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide, Science, vol.273, issue.5282, pp.1719-1722, 1996.
DOI : 10.1126/science.273.5282.1719

P. Derkinderen, E. Valjent, M. Toutant, J. C. Corvol, H. Enslen et al., Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus, J. Neurosci, vol.23, pp.2371-2382, 2003.

L. A. Devi, G-protein-coupled receptor dimers in the lime light, Trends in Pharmacological Sciences, vol.21, issue.9, pp.324-326, 2000.
DOI : 10.1016/S0165-6147(00)01519-4

T. P. Dinh, D. Carpenter, F. M. Leslie, T. F. Freund, I. Katona et al., Brain monoglyceride lipase participating in endocannabinoid inactivation, Proceedings of the National Academy of Sciences, vol.99, issue.16, pp.10819-10824, 2002.
DOI : 10.1073/pnas.152334899

M. Egertova, G. M. Simon, B. F. Cravatt, and M. R. Elphick, Localization ofN-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective onN-acylethanolamines as neural signaling molecules, The Journal of Comparative Neurology, vol.254, issue.4, pp.604-615, 2007.
DOI : 10.1002/cne.21568

J. Ellis, J. D. Pediani, M. Canals, S. Milasta, and G. Milligan, Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function, Journal of Biological Chemistry, vol.281, issue.50, pp.38812-38824, 2006.
DOI : 10.1074/jbc.M602494200

J. Fernandez-ruiz, F. Berrendero, M. L. Hernandez, and J. A. Ramos, The endogenous cannabinoid system and brain development, Trends in Neurosciences, vol.23, issue.1, pp.14-20, 2000.
DOI : 10.1016/S0166-2236(99)01491-5

I. Galve-roperh, T. Aguado, J. Palazuelos, and M. Guzman, The Endocannabinoid System and Neurogenesis in Health and Disease, The Neuroscientist, vol.160, issue.2, pp.109-114, 2007.
DOI : 10.1177/1073858406296407

T. Harkany, Endocannabinoids in the developing brain Date of submission, 2008.

I. Galve-roperh, T. Aguado, D. Rueda, G. Velasco, and M. Guzman, Endocannabinoids: A New Family of Lipid Mediators Involved in the Regulation of Neural Cell Development, Current Pharmaceutical Design, vol.12, issue.18, pp.2319-2325, 2006.
DOI : 10.2174/138161206777585139

I. Galve-roperh, C. Sanchez, M. L. Cortes, T. G. Del-pulgar, M. Izquierdo et al., Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation, Nat. Med, vol.6, pp.313-319, 2000.

S. Ghosh, A. Preet, J. E. Groopman, and R. K. Ganju, Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes, Molecular Immunology, vol.43, issue.14, pp.2169-2179, 2006.
DOI : 10.1016/j.molimm.2006.01.005

M. Guzman, Cannabinoids: potential anticancer agents, Nature Reviews Cancer, vol.3, issue.10, pp.745-755, 2003.
DOI : 10.1038/nrc1188

M. Guzman, C. Sanchez, and I. Galve-roperh, Control of the cell survival/death decision by cannabinoids, Journal of Molecular Medicine, vol.78, issue.11, pp.613-625, 2001.
DOI : 10.1007/s001090000177

M. Guzman, C. Sanchez, and I. Galve-roperh, Cannabinoids and cell fate, Pharmacology & Therapeutics, vol.95, issue.2, pp.175-184, 2002.
DOI : 10.1016/S0163-7258(02)00256-5

T. Harkany, M. Guzman, I. Galve-roperh, P. Berghuis, L. A. Devi et al., The emerging functions of endocannabinoid signaling during CNS development, Trends in Pharmacological Sciences, vol.28, issue.2, pp.83-92, 2007.
DOI : 10.1016/j.tips.2006.12.004

J. C. He, I. Gomes, T. Nguyen, G. Jayaram, P. T. Ram et al., The G??o/i-coupled Cannabinoid Receptor-mediated Neurite Outgrowth Involves Rap Regulation of Src and Stat3, Journal of Biological Chemistry, vol.280, issue.39, pp.33426-33434, 2005.
DOI : 10.1074/jbc.M502812200

C. Hsieh, S. Brown, C. Derleth, and K. Mackie, Internalization and Recycling of the CB1 Cannabinoid Receptor, Journal of Neurochemistry, vol.126, issue.9, pp.493-501, 1999.
DOI : 10.1046/j.1471-4159.1999.0730493.x

A. C. Huizink and E. J. Mulder, Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring, Neuroscience & Biobehavioral Reviews, vol.30, issue.1, pp.24-41, 2006.
DOI : 10.1016/j.neubiorev.2005.04.005

R. Iyengar, Teaching resources. Introduction: Overview of pathways and networks and GPCR signaling, Sci. STKE, p.4, 2005.

K. Jin, L. Xie, S. H. Kim, S. Parmentier-batteur, Y. Sun et al., Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice, Molecular Pharmacology, vol.66, issue.2, pp.204-208, 2004.
DOI : 10.1124/mol.66.2.204

D. G. Johns, D. J. Behm, D. J. Walker, Z. Ao, E. M. Shapland et al., The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects, British Journal of Pharmacology, vol.400, issue.5, pp.825-831, 2007.
DOI : 10.1038/sj.bjp.0707419

J. D. Jordan, J. C. He, N. J. Eungdamrong, I. Gomes, W. Ali et al., Cannabinoid Receptor-induced Neurite Outgrowth Is Mediated by Rap1 Activation through G??o/i-triggered Proteasomal Degradation of Rap1GAPII, Journal of Biological Chemistry, vol.280, issue.12, pp.11413-11421, 2005.
DOI : 10.1074/jbc.M411521200

I. Katona, G. M. Urban, M. Wallace, C. Ledent, K. M. Jung et al., Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses, Journal of Neuroscience, vol.26, issue.21, pp.5628-5637, 2006.
DOI : 10.1523/JNEUROSCI.0309-06.2006

A. C. Kreitzer and W. G. Regehr, Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells, Neuron, vol.29, issue.3, pp.717-727, 2001.
DOI : 10.1016/S0896-6273(01)00246-X

R. Kurihara, Y. Tohyama, S. Matsusaka, H. Naruse, E. Kinoshita et al., Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils, Journal of Biological Chemistry, vol.281, issue.18, pp.12908-12918, 2006.
DOI : 10.1074/jbc.M510871200

J. E. Lauckner, B. Hille, and K. Mackie, The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins, Proceedings of the National Academy of Sciences, vol.102, issue.52, pp.19144-19149, 2005.
DOI : 10.1073/pnas.0509588102

J. E. Lauckner, J. B. Jensen, H. Y. Chen, H. C. Lu, B. Hille et al., GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current Constitutive endocytic cycle of the CB1 cannabinoid receptor, Proc. Natl. Acad. Sci. U. S. J. Biol. Chem, vol.279, pp.36013-36021, 2004.

C. Leterrier, J. Laine, M. Darmon, H. Boudin, J. Rossier et al., Constitutive Activation Drives Compartment-Selective Endocytosis and Axonal Targeting of Type 1 Cannabinoid Receptors, Journal of Neuroscience, vol.26, issue.12, pp.3141-3153, 2006.
DOI : 10.1523/JNEUROSCI.5437-05.2006

URL : https://hal.archives-ouvertes.fr/hal-00250333

J. Liu, L. Wang, J. Harvey-white, D. Osei-hyiaman, R. Razdan et al., A biosynthetic pathway for anandamide, Proceedings of the National Academy of Sciences, vol.103, issue.36, pp.13345-13350, 2006.
DOI : 10.1073/pnas.0601832103

B. Lutz, On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures, Biochemical Pharmacology, vol.68, issue.9, pp.1691-1698, 2004.
DOI : 10.1016/j.bcp.2004.07.007

M. Maccarrone, S. Rossi, M. Bari, C. De, F. Fezza et al., Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum, Nature Neuroscience, vol.294, issue.2, pp.152-159, 2008.
DOI : 10.1038/nn2042

K. Mackie and N. Stella, Cannabinoid Receptors and Endocannabinoids: Evidence for New Players, The AAPS Journal, vol.08, issue.02, pp.298-306, 2006.
DOI : 10.1208/aapsj080234

S. Maione, T. Bisogno, N. De, E. Palazzo, L. Cristino et al., Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide Page 13 of 16, 2006.

T. Harkany, Endocannabinoids in the developing brain Date of submission, 2008.

I. Matias, D. Marzo, and V. , Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance, J. Endocrinol. Invest, vol.29, pp.15-26, 2006.

S. Mato, D. Olmo, E. Pazos, and A. , Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain, European Journal of Neuroscience, vol.29, issue.9, pp.1747-1754, 2003.
DOI : 10.1046/j.1460-9568.2003.02599.x

F. Matyas, G. M. Urban, M. Watanabe, K. Mackie, A. Zimmer et al., Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area, Neuropharmacology, vol.54, issue.1, pp.95-107, 2008.
DOI : 10.1016/j.neuropharm.2007.05.028

N. A. Mcdonald, C. M. Henstridge, C. N. Connolly, and A. J. Irving, An Essential Role for Constitutive Endocytosis, but Not Activity, in the Axonal Targeting of the CB1 Cannabinoid Receptor, Molecular Pharmacology, vol.71, issue.4, pp.976-984, 2007.
DOI : 10.1124/mol.106.029348

N. A. Mcdonald, C. M. Henstridge, C. N. Connolly, and A. J. Irving, Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging, Molecular and Cellular Neuroscience, vol.35, issue.2, pp.237-248, 2007.
DOI : 10.1016/j.mcn.2007.02.016

D. Mchugh, C. Tanner, R. Mechoulam, R. G. Pertwee, and R. A. Ross, Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB1 and CB2, Molecular Pharmacology, vol.73, issue.2, 2007.
DOI : 10.1124/mol.107.041863

G. Mereu, M. Fa, L. Ferraro, R. Cagiano, T. Antonelli et al., Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release, Proceedings of the National Academy of Sciences, vol.100, issue.8, pp.4915-4920, 2003.
DOI : 10.1073/pnas.0537849100

A. M. Miller and N. Stella, CB(2) receptor-mediated migration of immune cells: it can go either way, Br. J. Pharmacol, 2007.

E. Molina-holgado, J. M. Vela, A. Arevalo-martin, G. Almazan, F. Molina-holgado et al., Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling, J. Neurosci, vol.22, pp.9742-9753, 2002.

F. Molina-holgado, A. Rubio-araiz, D. Garcia-ovejero, R. J. Williams, J. D. Moore et al., CB2 cannabinoid receptors promote mouse neural stem cell proliferation, European Journal of Neuroscience, vol.26, issue.3, pp.629-634, 2007.
DOI : 10.1111/j.1460-9568.2007.05322.x

J. Morishita, Y. Okamoto, K. Tsuboi, M. Ueno, H. Sakamoto et al., Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain, Journal of Neurochemistry, vol.108, issue.69, pp.753-762, 2005.
DOI : 10.1111/j.1471-4159.2005.03234.x

Y. M. Morozov, B. Ari, Y. Freund, and T. F. , The spatial and temporal pattern of fatty acid amide hydrolase expression in rat hippocampus during postnatal development, European Journal of Neuroscience, vol.179, issue.2, pp.459-466, 2004.
DOI : 10.1126/science.1063545

URL : https://hal.archives-ouvertes.fr/inserm-00484661

G. G. Muccioli, C. Xu, E. Odah, E. Cudaback, J. A. Cisneros et al., Identification of a Novel Endocannabinoid-Hydrolyzing Enzyme Expressed by Microglial Cells, Journal of Neuroscience, vol.27, issue.11, pp.2883-2889, 2007.
DOI : 10.1523/JNEUROSCI.4830-06.2007

J. Mulder, T. Auguado, K. Barabas, E. Keimpema, C. J. Ballester-rosado et al., Endocannabinoid signaling is indispensable for pyramidal cell specification and long-range axon patterning, Proc Natl. Acad, 2008.

S. Munro, K. L. Thomas, and M. Abu-shaar, Molecular characterization of a peripheral receptor for cannabinoids, Nature, vol.365, issue.6441, pp.61-65, 1993.
DOI : 10.1038/365061a0

J. L. Niehaus, Y. Liu, K. T. Wallis, M. Egertova, S. G. Bhartur et al., CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a, Molecular Pharmacology, vol.72, issue.6, pp.1557-1566, 2007.
DOI : 10.1124/mol.107.039263

T. Ohno-shosaku, H. Tsubokawa, I. Mizushima, N. Yoneda, A. Zimmer et al., Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses, J. Neurosci, vol.22, pp.3864-3872, 2002.

S. Oka, K. Nakajima, A. Yamashita, S. Kishimoto, and T. Sugiura, Identification of GPR55 as a lysophosphatidylinositol receptor, Biochemical and Biophysical Research Communications, vol.362, issue.4, pp.928-934, 2007.
DOI : 10.1016/j.bbrc.2007.08.078

Y. Okamoto, J. Wang, J. Morishita, and N. Ueda, Biosynthetic Pathways of the Endocannabinoid Anandamide, Chemistry & Biodiversity, vol.103, issue.8, pp.1842-1857, 2007.
DOI : 10.1002/cbdv.200790155

D. Piomelli, The molecular logic of endocannabinoid signalling, Nature Reviews Neuroscience, vol.4, issue.11, pp.873-884, 2003.
DOI : 10.1038/nrn1247

A. Preet, R. K. Ganju, J. E. Groopman, P. Mukhopadhyay, G. Hasko et al., Delta(9)-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo CB(2) cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration, Oncogene Rajesh, Br. J. Pharmacol. Rimmerman, N, 2007.

T. Harkany, Endocannabinoids in the developing brain Date of submission, 2008.

M. Rinaldi-carmona, L. Duigou, A. Oustric, D. Barth, F. Bouaboula et al., Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system, J. Pharmacol. Exp. Ther, vol.287, pp.1038-1047, 1998.

C. Rios, I. Gomes, and L. A. Devi, ?? opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis, British Journal of Pharmacology, vol.72, issue.4, pp.387-395, 2006.
DOI : 10.1038/sj.bjp.0706757

J. P. Roche, S. Bounds, S. Brown, and K. Mackie, A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization, Mol. Pharmacol, vol.56, pp.611-618, 1999.

J. Romero, E. Garcia-palomero, F. Berrendero, L. Garcia-gil, M. L. Hernandez et al., Atypical location of cannabinoid receptors in white matter areas during rat brain development, Synapse, vol.307, issue.3, pp.317-323, 1997.
DOI : 10.1002/(SICI)1098-2396(199707)26:3<317::AID-SYN12>3.0.CO;2-S

D. Rueda, B. Navarro, A. Martinez-serrano, M. Guzman, and I. Galve-roperh, The Endocannabinoid Anandamide Inhibits Neuronal Progenitor Cell Differentiation through Attenuation of the Rap1/B-Raf/ERK Pathway, Journal of Biological Chemistry, vol.277, issue.48, pp.46645-46650, 2002.
DOI : 10.1074/jbc.M206590200

E. Ryberg, N. Larsson, S. Sjogren, S. Hjorth, N. O. Hermansson et al., The orphan receptor GPR55 is a novel cannabinoid receptor, British Journal of Pharmacology, vol.96, issue.69, pp.1092-1101, 2007.
DOI : 10.1038/sj.bjp.0707460

E. Ryberg, H. K. Vu, N. Larsson, T. Groblewski, S. Hjorth et al., Identification and characterisation of a novel splice variant of the human CB1 receptor, FEBS Letters, vol.278, issue.1, pp.259-264, 2005.
DOI : 10.1016/j.febslet.2004.11.085

B. Sampo, S. Kaech, S. Kunz, and G. Banker, Two Distinct Mechanisms Target Membrane Proteins to the Axonal Surface, Neuron, vol.37, issue.4, pp.611-624, 2003.
DOI : 10.1016/S0896-6273(03)00058-8

M. Sawzdargo, T. Nguyen, D. K. Lee, K. R. Lynch, R. Cheng et al., Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ??GPR53 and GPR55: GPR55 is extensively expressed in human brain, Molecular Brain Research, vol.64, issue.2, pp.193-198, 1999.
DOI : 10.1016/S0169-328X(98)00277-0

E. Seong, B. H. Wainer, E. D. Hughes, T. L. Saunders, M. Burmeister et al., Genetic Analysis of the Neuronal and Ubiquitous AP-3 Adaptor Complexes Reveals Divergent Functions in Brain, Molecular Biology of the Cell, vol.16, issue.1, pp.128-140, 2005.
DOI : 10.1091/mbc.E04-10-0892

G. M. Simon and B. F. Cravatt, Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for ??/beta-Hydrolase 4 in This Pathway, Journal of Biological Chemistry, vol.281, issue.36, pp.26465-26472, 2006.
DOI : 10.1074/jbc.M604660200

Z. H. Song and M. Zhong, CB1 cannabinoid receptor-mediated cell migration, J. Pharmacol. Exp. Ther, vol.294, pp.204-209, 2000.

L. A. Stoddart, A. J. Brown, and G. Milligan, Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5'-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist, Molecular Pharmacology, vol.71, issue.4, pp.994-1005, 2007.
DOI : 10.1124/mol.106.031534

G. Turu, A. Simon, P. Gyombolai, L. Szidonya, G. Bagdy et al., The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity, Journal of Biological Chemistry, vol.282, issue.11, pp.7753-7757, 2007.
DOI : 10.1074/jbc.C600318200

M. Uchigashima, M. Narushima, M. Fukaya, I. Katona, M. Kano et al., Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum, Journal of Neuroscience, vol.27, issue.14, pp.3663-3676, 2007.
DOI : 10.1523/JNEUROSCI.0448-07.2007

N. Ueda, Y. Okamoto, and J. Morishita, N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: A novel enzyme of the ??-lactamase fold family releasing anandamide and other N-acylethanolamines, Life Sciences, vol.77, issue.14, pp.1750-1758, 2005.
DOI : 10.1016/j.lfs.2005.05.018

H. Ujike, M. Takaki, K. Nakata, Y. Tanaka, T. Takeda et al., CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia Anandamide as an intracellular messenger regulating ion channel activity, Mol. Psychiatry Prostaglandins Other Lipid Mediat, vol.7, issue.77, pp.515-518, 2002.

J. Wager-miller, R. Westenbroek, and K. Mackie, Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example, Chemistry and Physics of Lipids, vol.121, issue.1-2, pp.83-89, 2002.
DOI : 10.1016/S0009-3084(02)00151-2

M. Waldhoer, P. Casarosa, M. M. Rosenkilde, M. J. Smit, R. Leurs et al., The Carboxyl Terminus of Human Cytomegalovirus-encoded 7 Transmembrane Receptor US28 Camouflages Agonism by Mediating Constitutive Endocytosis, Journal of Biological Chemistry, vol.278, issue.21, pp.19473-19482, 2003.
DOI : 10.1074/jbc.M213179200

L. Walter, A. Franklin, A. Witting, C. Wade, Y. Xie et al., Nonpsychotropic cannabinoid receptors regulate microglial cell migration, J. Neurosci, vol.23, pp.1398-1405, 2003.

X. Wang, D. Dow-edwards, E. Keller, and Y. L. Hurd, Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain, Neuroscience, vol.118, issue.3, pp.681-694, 2003.
DOI : 10.1016/S0306-4522(03)00020-4

S. Watson, D. Chambers, C. Hobbs, P. Doherty, and A. Graham, The cannabinoid receptor, CB1, is required for normal axonal growth and fasciculation, Mol. Cell Neurosci. in press, 2008.

B. Q. Wei, T. S. Mikkelsen, M. K. Mckinney, E. S. Lander, and B. F. Cravatt, A Second Fatty Acid Amide Hydrolase with Variable Distribution among Placental Mammals, Journal of Biological Chemistry, vol.281, issue.48, pp.36569-36578, 2006.
DOI : 10.1074/jbc.M606646200

M. Weiser and S. Noy, Interpreting the association between cannabis use and increased risk for schizophrenia, Dialogues. Clin. Neurosci, vol.7, pp.81-85, 2005.

J. L. Whistler, B. O. Gerber, E. C. Meng, T. J. Baranski, M. Von-zastrow et al., Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated Conformations of a G Protein-Coupled Receptor, Traffic, vol.3, issue.12, pp.866-877, 2002.
DOI : 10.1034/j.1600-0854.2002.31203.x

T. Harkany, Endocannabinoids in the developing brain Date of submission, 2008.

E. J. Williams, F. S. Walsh, and P. Doherty, The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response, The Journal of Cell Biology, vol.108, issue.4, pp.481-486, 2003.
DOI : 10.1038/47501

R. I. Wilson, G. Kunos, and R. A. Nicoll, Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus, Neuron, vol.31, issue.3, pp.453-462, 2001.
DOI : 10.1016/S0896-6273(01)00372-5

R. I. Wilson and R. A. Nicoll, correction: Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, Nature, vol.410, issue.6840, pp.588-592, 2001.
DOI : 10.1038/35082121

D. Wisco, E. D. Anderson, M. C. Chang, C. Norden, T. Boiko et al., Uncovering multiple axonal targeting pathways in hippocampal neurons, The Journal of Cell Biology, vol.17, issue.7, pp.1317-1328, 2003.
DOI : 10.1038/17806