P. Afonso, S. Ozden, M. Prevost, C. Schmitt, D. Seilhean et al., Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies, J Immunol Mol Pharmacol J Cereb Blood Flow Metab, vol.1797328, pp.2576-831424, 2007.

C. Forster, M. Burek, I. Romero, B. Weksler, P. Couraud et al., model of the human blood-brain barrier, The Journal of Physiology, vol.89, issue.Suppl. 2, pp.1937-1986, 2008.
DOI : 10.1113/jphysiol.2007.146852

J. Scherrmann, Expression and function of multidrug resistance transporters at the blood???brain barriers, Expert Opinion on Drug Metabolism & Toxicology, vol.1, issue.8, pp.233-279, 2005.
DOI : 10.2174/1381612043384844

S. Seetharaman, M. Barrand, L. Maskell, R. Scheper, R. Bendayan et al., Multidrug Resistance-Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates, situ localization of Pglycoprotein (ABCB1) in human and rat brain, pp.1151-91159, 1998.
DOI : 10.1046/j.1471-4159.1998.70031151.x

G. Lee, K. Babakhanian, M. Ramaswamy, A. Prat, K. Wosik et al., Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems Localisation of breast cancer resistance protein in microvessel endothelium of human brain, Pharm Res Neuroreport, vol.2413, pp.1262-742059, 2002.

Y. Zhang, H. Han, W. Elmquist, and D. Miller, Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells, Brain Research, vol.876, issue.1-2, pp.148-53, 2000.
DOI : 10.1016/S0006-8993(00)02628-7

H. Bronger, J. Konig, K. Kopplow, H. Steiner, R. Ahmadi et al., ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier, Cancer Research, vol.65, issue.24, pp.11419-11447, 2005.
DOI : 10.1158/0008-5472.CAN-05-1271

B. Weksler, E. Subileau, N. Perriere, P. Charneau, K. Holloway et al., Blood-brain barrier-specific properties of a human adult brain endothelial cell line, The FASEB Journal, vol.19, pp.1872-1876, 2005.
DOI : 10.1096/fj.04-3458fje

R. Bacha and A. Minn, Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain, Cell Mol Biol, vol.1345, pp.15-23, 1999.

F. Dutheil, P. Beaune, and M. Loriot, Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain, Biochimie, vol.90, issue.3, pp.426-462, 2008.
DOI : 10.1016/j.biochi.2007.10.007

J. Ghersi-egea, B. Leninger-muller, G. Suleman, G. Siest, and A. Minn, Localization of Drug-Metabolizing Enzyme Activities to Blood-Brain Interfaces and Circumventricular Organs, Journal of Neurochemistry, vol.124, issue.3, pp.1089-96, 1994.
DOI : 10.1046/j.1471-4159.1994.62031089.x

L. Granberg, A. Ostergren, I. Brandt, and E. Brittebo, CYP1A1 and CYP1B1 in Blood-Brain Interfaces: CYP1A1-Dependent Bioactivation of 7,12-Dimethylbenz(a)anthracene in Endothelial Cells, Drug Metabolism and Disposition, vol.31, issue.3, pp.259-65, 2003.
DOI : 10.1124/dmd.31.3.259

C. Xu, C. Li, and A. Kong, Induction of phase I, II and III drug metabolism/transport by xenobiotics, Archives of Pharmacal Research, vol.182, issue.481, pp.249-68, 2005.
DOI : 10.1007/BF02977789

B. Bauer, A. Hartz, G. Fricker, and D. Miller, Pregnane X receptor up-regulation of Pglycoprotein expression and transport function at the blood-brain barrier, Mol Pharmacol, vol.66, pp.413-422, 2004.

S. Akanuma, S. Hori, S. Ohtsuki, M. Fujiyoshi, and T. Terasaki, Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood???brain barrier, Neurochemistry International, vol.52, issue.4-5, pp.669-74, 2008.
DOI : 10.1016/j.neuint.2007.08.012

C. Filbrandt, Z. Wu, B. Zlokovic, L. Opanashuk, and T. Gasiewicz, Presence and Functional Activity of the Aryl Hydrocarbon Receptor in Isolated Murine Cerebral Vascular Endothelial Cells and Astrocytes, NeuroToxicology, vol.25, issue.4, pp.605-621, 2004.
DOI : 10.1016/j.neuro.2003.08.007

J. Zastre, G. Chan, P. Ronaldson, M. Ramaswamy, P. Couraud et al., Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line, Journal of Neuroscience Research, vol.306, issue.4, 2008.
DOI : 10.1002/jnr.21898

S. Dauchy, F. Dutheil, R. Weaver, P. Couraud, J. Scherrmann et al., ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier, Journal of Neurochemistry, vol.876, issue.6, 2008.
DOI : 10.1111/j.1471-4159.2008.05720.x

I. Girault, N. Rougier, C. Chesne, R. Lidereau, P. Beaune et al., Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction, Drug Metab Dispos, vol.33, pp.1803-1813, 2005.

M. Roth, J. Marques-magallanes, M. Yuan, W. Sun, D. Tashkin et al., -Tetrahydrocannabinol, American Journal of Respiratory Cell and Molecular Biology, vol.24, issue.3, pp.339-383, 2001.
DOI : 10.1165/ajrcmb.24.3.4252

URL : https://hal.archives-ouvertes.fr/hal-00259673

P. Olinga, M. Elferink, A. Draaisma, M. Merema, J. Castell et al., Coordinated induction of drug transporters and phase I and II metabolism in human liver slices, European Journal of Pharmaceutical Sciences, vol.33, issue.4-5, pp.380-389, 2008.
DOI : 10.1016/j.ejps.2008.01.008

E. Jigorel, L. Vee, M. Boursier-neyret, C. Parmentier, Y. Fardel et al., Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes, Drug Metabolism and Disposition, vol.34, issue.10, pp.1756-63, 2006.
DOI : 10.1124/dmd.106.010033

URL : https://hal.archives-ouvertes.fr/hal-00699523

B. Ebert, A. Seidel, and A. Lampen, Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists, Carcinogenesis, vol.26, issue.10, pp.1754-63, 2005.
DOI : 10.1093/carcin/bgi139

T. Chang and D. Waxman, Enzymatic Analysis of cDNA-Expressed Human CYP1A1, CYP1A2, and CYP1B1 With 7-Ethoxyresorufin as Substrate, Methods Mol Biol, vol.107, pp.103-112, 1998.
DOI : 10.1385/1-59259-998-2:85

B. Walther, J. Ghersi-egea, A. Minn, and G. Siest, Subcellular distribution of cytochrome P-450 in the brain, Brain Research, vol.375, issue.2, pp.338-382, 1986.
DOI : 10.1016/0006-8993(86)90754-7

D. Virgintino, D. Robertson, M. Errede, V. Benagiano, F. Girolamo et al., Expression of P-Glycoprotein in Human Cerebral Cortex Microvessels, Journal of Histochemistry & Cytochemistry, vol.21, issue.12, pp.1671-1677, 2002.
DOI : 10.1177/38.9.1974900

W. Zhang, J. Mojsilovic-petrovic, M. Andrade, H. Zhang, M. Ball et al., Expression and functional characterization of ABCG2 in brain endothelial cells and vessels, The FASEB Journal, vol.17, pp.2085-2092, 2003.
DOI : 10.1096/fj.02-1131fje

L. Cucullo, M. Hossain, E. Rapp, T. Manders, N. Marchi et al., Development of a Humanized In Vitro Blood?Brain Barrier Model to Screen for Brain Penetration of Antiepileptic Drugs, Epilepsia, vol.296, issue.3, pp.505-521, 2007.
DOI : 10.1111/j.1528-1157.1996.tb00586.x

L. Doyle, W. Yang, L. Abruzzo, T. Krogmann, Y. Gao et al., A multidrug resistance transporter from human MCF-7 breast cancer cells, Proceedings of the National Academy of Sciences, vol.95, issue.26, pp.15665-70, 1998.
DOI : 10.1073/pnas.95.26.15665

A. Nies, G. Jedlitschky, J. Konig, C. Herold-mende, H. Steiner et al., Expression and immunolocalization of the multidrug resistance proteins, ABCC1-ABCC6), in human brain, pp.1-6349, 2004.

M. Karlgren, M. Backlund, I. Johansson, M. Oscarson, and M. Ingelman-sundberg, Characterization and tissue distribution of a novel human cytochrome P450???CYP2U1, Biochemical and Biophysical Research Communications, vol.315, issue.3, pp.679-85, 2004.
DOI : 10.1016/j.bbrc.2004.01.110

S. Chuang, C. Helvig, M. Taimi, H. Ramshaw, A. Collop et al., CYP2U1, a Novel Human Thymus- and Brain-specific Cytochrome P450, Catalyzes ??- and (??-1)-Hydroxylation of Fatty Acids, Journal of Biological Chemistry, vol.279, issue.8, pp.6305-6319, 2004.
DOI : 10.1074/jbc.M311830200

M. Karlgren, S. Miura, and M. Ingelman-sundberg, Novel extrahepatic cytochrome P450s, Toxicology and Applied Pharmacology, vol.207, issue.2, pp.57-61, 2005.
DOI : 10.1016/j.taap.2004.12.022

B. Urquhart, R. Tirona, and R. Kim, Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs, The Journal of Clinical Pharmacology, vol.70, issue.5, pp.566-78, 2007.
DOI : 10.1177/0091270007299930

J. Lamba, V. Lamba, K. Yasuda, Y. Lin, M. Assem et al., Expression of Constitutive Androstane Receptor Splice Variants in Human Tissues and Their Functional Consequences, Journal of Pharmacology and Experimental Therapeutics, vol.311, issue.2, pp.811-832, 2004.
DOI : 10.1124/jpet.104.069310

S. Teng, V. Jekerle, and M. Piquette-miller, INDUCTION OF ABCC3 (MRP3) BY PREGNANE X RECEPTOR ACTIVATORS, Drug Metabolism and Disposition, vol.31, issue.11, pp.1296-1305, 2003.
DOI : 10.1124/dmd.31.11.1296

S. Dombrowski, S. Desai, M. Marroni, L. Cucullo, K. Goodrich et al., Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy, Epilepsia, vol.28, issue.suppl 4, pp.1501-1507, 2001.
DOI : 10.1046/j.1528-1157.2001.12301.x

A. Geick, M. Eichelbaum, and O. Burk, Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin, Journal of Biological Chemistry, vol.276, issue.18, pp.14581-14588, 2001.
DOI : 10.1074/jbc.M010173200

H. Kast, B. Goodwin, P. Tarr, S. Jones, A. Anisfeld et al., Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor, Journal of Biological Chemistry, vol.277, issue.4, pp.2908-2923, 2002.
DOI : 10.1074/jbc.M109326200

B. Bauer, X. Yang, A. Hartz, E. Olson, R. Zhao et al., In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation, Molecular Pharmacology, vol.70, issue.4, pp.1212-1221, 2006.
DOI : 10.1124/mol.106.023796

B. Bauer, A. Hartz, J. Lucking, X. Yang, G. Pollack et al., Coordinated Nuclear Receptor Regulation of the Efflux Transporter, Mrp2, and the Phase-Ii Metabolizing Enzyme, GST??, at the Blood???Brain Barrier, Journal of Cerebral Blood Flow & Metabolism, vol.311, issue.6, pp.1222-1256, 2008.
DOI : 10.1128/MCB.24.17.7612-7621.2004

B. Bauer, A. Hartz, G. Fricker, and D. Miller, Modulation of p-glycoprotein transport function at the blood-brain barrier, Exp Biol Med (Maywood), vol.230, pp.118-145, 2005.

K. Kojima, K. Nagata, T. Matsubara, and Y. Yamazoe, Broad but Distinct Role of Pregnane X Receptor on the Expression of Individual Cytochrome P450s in Human Hepatocytes, Drug Metabolism and Pharmacokinetics, vol.22, issue.4, pp.276-86, 2007.
DOI : 10.2133/dmpk.22.276

J. Lehmann, D. Mckee, M. Watson, T. Willson, J. Moore et al., The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions Induction of CYP2C genes in human hepatocytes in primary culture, J Clin Invest Drug Metab Dispos, vol.1024929, issue.12, pp.1016-23242, 1998.

A. Annas, A. Granberg, and E. Brittebo, Differential Response of Cultured Human Umbilical Vein and Artery Endothelial Cells to Ah Receptor Agonist Treatment: CYP-Dependent Activation of Food and Environmental Mutagens, Toxicology and Applied Pharmacology, vol.169, issue.1, pp.94-101, 2000.
DOI : 10.1006/taap.2000.9054

D. Nebert, T. Dalton, A. Okey, and F. Gonzalez, Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer, Journal of Biological Chemistry, vol.279, issue.23, pp.23847-50, 2004.
DOI : 10.1074/jbc.R400004200

C. Rieder, R. Parsons, N. Fitch, A. Williams, and D. Ramsden, Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM), Neuroscience Letters, vol.278, issue.3
DOI : 10.1016/S0304-3940(99)00932-5

M. Mcfadyen, S. Breeman, S. Payne, C. Stirk, I. Miller et al., Immunohistochemical Localization of Cytochrome P450 CYP1B1 in Breast Cancer with Monoclonal Antibodies Specific for CYP1B1, Journal of Histochemistry & Cytochemistry, vol.26, issue.11, pp.1457-64, 1999.
DOI : 10.1136/gut.43.6.791

R. Edwards, D. Adams, P. Watts, D. Davies, and A. Boobis, Development of a Comprehensive Panel of Antibodies against the Major Xenobiotic Metabolising Forms of Cytochrome P450 in Humans, Biochemical Pharmacology, vol.56, issue.3, pp.377-87, 1998.
DOI : 10.1016/S0006-2952(98)00033-1

M. Mcfadyen, P. Rooney, W. Melvin, and G. Murray, Quantitative analysis of the Ah receptor/cytochrome P450 CYP1B1/CYP1A1 signalling pathway, Biochemical Pharmacology, vol.65, issue.10, pp.1663-74, 2003.
DOI : 10.1016/S0006-2952(03)00111-4

R. Meyer, M. Podvinec, and U. Meyer, Cytochrome P450 CYP1A1 Accumulates in the Cytosol of Kidney and Brain and Is Activated by Heme, Molecular Pharmacology, vol.62, issue.5, pp.1061-1068, 2002.
DOI : 10.1124/mol.62.5.1061

R. Meyer, R. Lindberg, F. Hoffmann, and U. Meyer, Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency, Biological Chemistry, vol.386, issue.11, pp.1157-64, 2005.
DOI : 10.1515/BC.2005.132

T. Shimada and Y. Fujii-kuriyama, Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1, Cancer Science, vol.12, issue.1, pp.1-6, 2004.
DOI : 10.1126/science.275.5297.218

S. Rivera, S. Saarikoski, and O. Hankinson, Identification of a Novel Dioxin-Inducible Cytochrome P450, Molecular Pharmacology, vol.61, issue.2, pp.255-264, 2002.
DOI : 10.1124/mol.61.2.255

J. Maher, X. Cheng, A. Slitt, M. Dieter, and C. Klaassen, INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER, Drug Metabolism and Disposition, vol.33, issue.7, pp.956-62, 2005.
DOI : 10.1124/dmd.105.003798