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Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives

Abstract : The synthesis of new pyrazolo[3,4-g]quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and three human solid cancer cell lines (PA1, PC3 and DU145) are described. The results obtained in this preliminary structure–activity relationship study have pointed out that most of the compounds in this series exhibited interesting in vitro Pim-3 kinase inhibitory potencies. Moreover, some of the tested compounds have demonstrated favorable antiproliferative potencies.
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Contributor : Stéphanie Bonnefoy <>
Submitted on : Friday, October 29, 2010 - 2:44:02 PM
Last modification on : Wednesday, March 4, 2020 - 11:26:39 AM


  • HAL Id : hal-00530614, version 1



Laurent Gavara, Emmanuelle Saugues, Georges Alves, Eric Debiton, Fabrice Anizon, et al.. Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives. Eur. J. Med. Chem., 2010, 45, pp.5520-5526. ⟨hal-00530614⟩



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