Anticoccidial constituents from the stem bark of Turraeanthus africanus

J. C. Vardamides (1) , Hicham El Alaoui (2) , D. L. Massoma (3) , A. G. B. Azebaze (1) , B. Ndemangou (4) , V. T. Sielinou (4) , M. Meyer (5) , Christian Vivarès (2) , Z. T. Fomum (4) , A. E. Nkengfack (4)

1 Department of Chemistry - Faculty of Science
2 LMGE - Laboratoire Microorganismes : Génome et Environnement
3 Department of Biology of Animal Organisms - Faculty of Science
4 Department of Organic Chemistry - Faculty of Science
5 Laboratoire de chimie et biochimie des substances naturelles

In order to study some biological active products, phytochemical investigation of the stem bark of Turraeanthus africanus have led to the isolation of a novel compound 1, a new benzoic acid derivative, named turraeanthin C, and two known compounds sesamin (2) and stigmasterol. The structures of these compounds were established by spectral analysis, including two-dimensional nuclear magnetic resonance. The extract and the isolated compounds 1 and 2 showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals.

Mots clés: anticoccidial activity; Turraeanthus africanus; benzoic acid derivative; Meliaceae

Domaines: Microbiologie et Parasitologie

J. C. Vardamides, Hicham El Alaoui, D. L. Massoma, A. G. B. Azebaze, B. Ndemangou, et al.. Anticoccidial constituents from the stem bark of Turraeanthus africanus. Chemistry of Natural Compounds, 2008, 44 (6), pp.696-700. ⟨hal-00529781⟩