Indirect and direct catalytic asymmetric reductive amination of 2-tetralone

O. Bondarev (1) , Christian Bruneau (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

Herein we report a one-pot catalytic asymmetric reductive amination of 2-tetralone. High-throughput screening of a small library of chiral ligands allowed us to perform the enantioselective hydrogenation of the intermediate enamine with up to 60% ee and a one-pot reaction with up to 47% enantiomeric excess of the desired amine.

Domaines: Catalyse

O. Bondarev, Christian Bruneau. Indirect and direct catalytic asymmetric reductive amination of 2-tetralone. Tetrahedron: Asymmetry, 2010, 21, pp.1350­-1354. ⟨10.1016/j.tetasy.2010.03.027⟩. ⟨hal-00527829⟩