Dysbiosis in inflammatory bowel disease: a role for bacteriophages?

Patricia Lepage (1) , J. Colombet (2) , P. Marteau (3) , Télesphore Sime-Ngando (2) , J. Doré (1) , M. Leclerc (1)

1 Unité d'écologie et physiologie du système digestif (LEPSD)
2 LMGE - Laboratoire Microorganismes : Génome et Environnement
3 AP-HP, Hôpital Lariboisière

Intestinal bacteria have been implicated in theinitiation and amplification of inflammatory bowel disease (IBD). The dysbiosis theory, reviewed by Tamboli et al (Gut 2004;53:1), is that an imbalance between putative ‘‘harmful'' versus ‘‘protective'' bacterial species may promote chronic intestinal inflammation.

Domaines: Biodiversité et Ecologie

Patricia Lepage, J. Colombet, P. Marteau, Télesphore Sime-Ngando, J. Doré, et al.. Dysbiosis in inflammatory bowel disease: a role for bacteriophages?. Gut, 2008, 57 (3), pp.424-5. ⟨10.1136/gut.2007.134668⟩. ⟨hal-00526557⟩