Identification of a new protein in the centrosome-like "atractophore" of Trichomonas vaginalis.

Geneviève Bricheux (1) , Gérard Coffe (1) , Guy Brugerolle (1)

1 LMGE - Laboratoire Microorganismes : Génome et Environnement

The human parasite Trichomonas vaginalis has specific structural bodies, atractophores, associated at one end to the kinetosomes and at the other to the spindle during division. A monoclonal antibody specific for a component of this structure was obtained. It recognizes a protein with a predicted molecular mass of 477 kDa. Sequence analysis of this protein shows that P477 belongs to the family of large coiled-coil proteins, sharing a highly versatile protein folding motif adaptable to many biological functions. P477-might act as an anchor to localize cellular activities and components to the golgi centrosomal region. It may represent a new class of structural proteins, since similar proteins were found in many protozoans.

Domaines: Protistologie

Geneviève Bricheux, Gérard Coffe, Guy Brugerolle. Identification of a new protein in the centrosome-like "atractophore" of Trichomonas vaginalis.. Molecular and Biochemical Parasitology, 2007, 153 (2), pp.133-40. ⟨10.1016/j.molbiopara.2007.02.011⟩. ⟨hal-00526075⟩