Fluorinated squaraine as near-IR label with improved properties for the labeling of oligonucleotides

Abstract : A new squaraine dye with fluorinated benzothiazole rings was synthesized. This new label possesses improved photophysical properties and chemical stability as compared to the corresponding non-fluorinated and the dicyanosquaraines. These squaraines were used for the labeling of a series of oligonucleotides with various sequences, lengths, and chemistries. The conjugates involving the fluorinated squaraine possess the best properties: emission wavelength >670 nm, high quantum yields (0.27-0.39).
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00525220
Contributor : Isabelle Frapart <>
Submitted on : Monday, October 11, 2010 - 2:02:26 PM
Last modification on : Wednesday, June 27, 2018 - 8:24:02 AM

Identifiers

Collections

Citation

Brice-Loïc Renard, Yves Aubert, Ulysse Asseline. Fluorinated squaraine as near-IR label with improved properties for the labeling of oligonucleotides. Tetrahedron Letters, Elsevier, 2009, 50 (17), pp.1897-1901. ⟨10.1016/j.tetlet.2009.02.029⟩. ⟨hal-00525220⟩

Share

Metrics

Record views

66