Mathematical and numerical modeling of early atherosclerotic lesions

Abstract : This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work \cite{CEMR} that was mainly restricted to a one-dimensional setting, we couple a simple lesion growth model relying on the biomolecular process that takes place in the intima with blood flow dynamics and mass transfer. We perform numerical simulations on a two-dimensional geometry taken from \cite{Cheng2005, Cheng2006} that mimicks a carotid artery deformed by a perivascular cast and we compare the numerical results with experimental data.
Type de document :
Article dans une revue
ESAIM: Proceedings, EDP Sciences, 2010, 30, pp.1-14
Liste complète des métadonnées

Littérature citée [19 références]  Voir  Masquer  Télécharger
Contributeur : Nicolas Meunier <>
Soumis le : lundi 4 octobre 2010 - 22:39:40
Dernière modification le : jeudi 7 février 2019 - 16:39:41
Document(s) archivé(s) le : jeudi 25 octobre 2012 - 16:30:37


Fichiers produits par l'(les) auteur(s)


  • HAL Id : hal-00523348, version 1



Vincent Calvez, Jean-Gabriel Houot, Nicolas Meunier, Annie Raoult, Gabriela Rusnakova. Mathematical and numerical modeling of early atherosclerotic lesions. ESAIM: Proceedings, EDP Sciences, 2010, 30, pp.1-14. 〈hal-00523348〉



Consultations de la notice


Téléchargements de fichiers