Apoptotic activity of a nuclear form of mitogaligin, a cell death protein

Abstract : Galig, an internal gene to the galectin-3 gene, encodes two proteins and induces cell death in human cells. Mitogaligin, one of these proteins, contains a mitochondrial targeting sequence and promotes the release of cytochrome c into the cytosol. Here, we show that mitogaligin can also localize to nucleus. The nuclear form of mitogaligin induced cell death through a pathway exhibiting typical properties of apoptosis. These observations indicate for the first time that mitogaligin expresses cytotoxic properties not only when addressed to mitochondria but also when targeted to the nucleus.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00522444
Contributor : Isabelle Frapart <>
Submitted on : Thursday, September 30, 2010 - 4:26:14 PM
Last modification on : Thursday, June 20, 2019 - 7:50:03 AM

Identifiers

Collections

Citation

Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, Elsevier, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩

Share

Metrics

Record views

70