Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

Abstract : We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-alpha-aminopropionate, and the relaxometric characterization of its Gd3+ complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.
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Submitted on : Thursday, September 30, 2010 - 3:27:48 PM
Last modification on : Friday, October 11, 2019 - 2:14:06 PM

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Miguel Ferreira, Andre Martins, A. Martins Jose, Paula Ferreira, Éva Tóth, et al.. Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents. Chemical Communications, Royal Society of Chemistry, 2009, pp.6475-6477. ⟨10.1039/b912201j⟩. ⟨hal-00522392⟩

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