Novel neutral imidazole-lipophosphoramides for transfection assays

M. Mevel (1) , C. Neveu , Cristine Goncalves (2) , J.-J. Yaouanc (1) , Chantal Pichon (2) , Paul-Alain Jaffres (1) , Patrick Midoux (2)

1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 CBM - Centre de biophysique moléculaire

New helper lipids, possessing an imidazole polar head, have been synthesized and included in formulations for transfection assays; these new helper lipids can improve the transfection by a factor of up to 100 compared to the use of DOPE as co-lipid.

M. Mevel, C. Neveu, Cristine Goncalves, J.-J. Yaouanc, Chantal Pichon, et al.. Novel neutral imidazole-lipophosphoramides for transfection assays. Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩. ⟨hal-00518192⟩