Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Alzheimer's Disease Année : 2010

Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

Résumé

In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol fromthe latter.Other compounds, such as kynurenic acid, serotonin, andmelatonin are produced via the same pathways. An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases. This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients. These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease. Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease.
Fichier non déposé

Dates et versions

hal-00517802 , version 1 (15-09-2010)

Identifiants

  • HAL Id : hal-00517802 , version 1

Citer

S. Duleu, A. Mangas, F. Sevin, B. Veyret, A. Bessede, et al.. Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease. International Journal of Alzheimer's Disease, 2010, pp.1-6. ⟨hal-00517802⟩
126 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More