Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.

Aude Ferran (1) , Véronique Dupouy-Guiraute (1) , Pierre-Louis Toutain (1) , Alain Bousquet‐mélou (1)

1 Physiologie et Toxicologie Expérimentales

We demonstrate using an in vitro pharmacodynamic model that the likelihood of selection of Escherichia coli mutants resistant to a fluoroquinolone was increased when the initial size of the bacterial population, exposed to fluoroquinolone concentrations within the mutant selection window, was increased.

Domaines: Pharmacologie

Aude Ferran, Véronique Dupouy-Guiraute, Pierre-Louis Toutain, Alain Bousquet‐mélou. Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.. Antimicrobial Agents and Chemotherapy, 2007, 51 (11), pp.4163-6. ⟨10.1128/AAC.00156-07⟩. ⟨hal-00517559⟩