Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, vol.44, issue.4, pp.601-607, 2004. ,
DOI : 10.1016/j.neuron.2004.11.005
Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, vol.44, issue.4, pp.595-600, 2004. ,
DOI : 10.1016/j.neuron.2004.10.023
LRRK2 in Parkinson's disease: protein domains and functional insights, Trends in Neurosciences, vol.29, issue.5, pp.286-293, 2006. ,
DOI : 10.1016/j.tins.2006.03.006
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study, Lancet Neurol, vol.7, pp.583-590, 2008. ,
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1792, issue.7, 2008. ,
DOI : 10.1016/j.bbadis.2008.09.015
in publicly available Parkinson's disease cases and neurologically normal controls, Human Mutation, vol.44, issue.4, pp.485-490, 2008. ,
DOI : 10.1002/humu.20668
LRRK2 in Parkinson???s disease: biochemical functions, FEBS Journal, vol.9, issue.22, pp.6428-6435, 2009. ,
DOI : 10.1111/j.1742-4658.2009.07341.x
From The Cover: Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity, Proceedings of the National Academy of Sciences, vol.102, issue.46, pp.16842-16847, 2005. ,
DOI : 10.1073/pnas.0507360102
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin, Neurobiology of Disease, vol.23, issue.2, pp.329-341, 2006. ,
DOI : 10.1016/j.nbd.2006.04.001
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity, Biochemical Journal, vol.405, issue.2, pp.307-317, 2007. ,
DOI : 10.1042/BJ20070209
URL : https://hal.archives-ouvertes.fr/hal-00478755
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease, Biochemical Journal, vol.320, issue.1, pp.47-60, 2009. ,
DOI : 10.1042/BJ20070797
Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors, Journal of Virological Methods, vol.138, issue.1-2, pp.85-98, 2006. ,
DOI : 10.1016/j.jviromet.2006.07.024
Differential 14-3-3-affinity capture reveals new downstream targets of PI 3-kinase signaling, as manuscript BJ20100483 THIS IS NOT THE VERSION OF RECORD -see doi, p.10, 1042. ,
Copying is not permitted, except with prior permission and as allowed by law, p.14 ,
Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins, The Plant Journal, vol.10, issue.970, pp.1-12, 1999. ,
DOI : 10.1074/jbc.272.43.27281
The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2, Journal of Neuroscience, vol.28, issue.13, pp.3384-3391, 2008. ,
DOI : 10.1523/JNEUROSCI.0185-08.2008
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation, J Cell Sci, vol.119, pp.4059-4070, 2006. ,
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes, Biochemical Journal, vol.381, issue.2, pp.329-342, 2004. ,
DOI : 10.1042/BJ20031332
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity, Cell, vol.91, issue.7, pp.961-971, 1997. ,
DOI : 10.1016/S0092-8674(00)80487-0
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model, Human Molecular Genetics, vol.18, issue.21, pp.4022-4034, 2009. ,
DOI : 10.1093/hmg/ddp346
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice, Proceedings of the National Academy of Sciences, vol.106, issue.34, pp.14622-14627, 2009. ,
DOI : 10.1073/pnas.0906334106
Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding, FEBS Letters, vol.7, issue.1-3, pp.267-271, 2002. ,
DOI : 10.1016/S0014-5793(02)03327-6
Specific acidic proteins of the nerous system. Pysiological and Biochemical Aspects of Nervous Integration, pp.343-359, 1967. ,
14-3-3 proteins in the nervous system, Nature Reviews Neuroscience, vol.4, issue.9, 2003. ,
DOI : 10.1038/nrn1197
Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1, Cell, vol.113, issue.4, pp.457-468, 2003. ,
DOI : 10.1016/S0092-8674(03)00349-0
3-3eta is a novel regulator of parkin ubiquitin ligase, EMBO J, vol.14, issue.25, pp.211-221, 2006. ,
) alpha-Synuclein shares physical and functional homology with 14-3-3 proteins, J Neurosci, vol.19, pp.5782-5791, 1999. ,
14-3-3 protein is a component of Lewy bodies in Parkinson???s disease???Mutation analysis and association studies of 14-3-3 eta, Molecular Brain Research, vol.108, issue.1-2, pp.33-39, 2002. ,
DOI : 10.1016/S0169-328X(02)00510-7
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death and Disease, ) Leucine-rich repeat kinase 2 (LRRK2) interacts with Biochemical Journal Immediate Publication, 2005. ,
Copying is not permitted, except with prior permission and as allowed by law. parkin, and mutant LRRK2 induces neuronal degeneration, Proc Natl Acad Sci, vol.102, pp.18676-18681 ,
LRRK2emph Exon 41 Mutations in Sporadic Parkinson Disease in Europeans, Archives of Neurology, vol.64, issue.3, pp.425-430, 2007. ,
DOI : 10.1001/archneur.64.3.425
Reevaluation of phosphorylation sites in the Parkinson's disease associated leucine rich repeat kinase-2, J Biol Chem, vol.34 ,
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification, Nature Biotechnology, vol.7, issue.12, pp.1367-1372, 2008. ,
DOI : 10.1038/nprot.2007.261
Copying is not permitted, except with prior permission and as allowed by law ,