Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population.

R. Lakhdar (1) , S. Denden (1) , J. Knani (1) , N. Leban (1) , H. Daimi (1) , M. Hassine (1) , G. Lefranc (1, 2) , J. Ben Chibani (3) , A. Haj Khelil (1)

1 BMBL - Biochemistry and Molecular Biology Laboratory
2 IGH - Institut de génétique humaine
3 DPM - Département de pharmacochimie moléculaire

GSTM1 and GSTT1 polymorphisms have been proposed in relationship with chronic obstructive pulmonary disease (COPD). We investigated the association between these polymorphisms and COPD (as well as its subtypes emphysema and chronic bronchitis) in 234 COPD patients and 182 healthy controls in the Tunisian population. Genotyping was performed using multiplex PCR. GSTM1-null genotype frequency was significantly higher in COPD patients than in controls (P = 0.02); however, multivariate analysis of cofounding variables showed no independent association with this genotype (P = 0.073). In contrast, the association of the GSTM1-null genotype with emphysema was significant, even after adjustment for risk factors (P = 0.011). There were no significant differences in GSTT1 genotypes between patients and controls. The GSTM1 null allele is likely not an independent risk factor for COPD but is related to emphysema, whereas the GSTT1 gene is not associated with the disease.

Domaines: Génétique humaine

R. Lakhdar, S. Denden, J. Knani, N. Leban, H. Daimi, et al.. Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population.. Biochemical Genetics, 2010, 48 (7-8), pp.647-657. ⟨10.1007/s10528-010-9346-z⟩. ⟨hal-00509803⟩